2-溴-4-(1,3-二氧代-1,3-二氢-2H-异吲哚-2-基)丁酸合成路线 （共 6 条）
反应条件
phosphorus; bromine in tetrachloromethane Heating6-8 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 14 p. 4246 - 4255
反应条件
1: 36 percent / Na2CO3 / H2O / 6 h 2: 80 percent / Br2, red P / CCl4 / 80 deg C, 30 min, reflux 8 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 5 p. 2078 - 2089
反应条件
sulfuric acid; potassium bromide; sodium nitrite T=0°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 21 p. 2765 - 2770
反应条件
1: triethylamine / toluene / 18 h / 110 °C 2: bromine; phosphorus / tetrachloromethane / 9 h / 60 °C View Scheme
参考文献
WO2012/38944 A1, ;
WO 2012/038944 A1
参考文献
Laliberte,R.; Berlinguet,L.
Canadian Journal of Chemistry, 1960 , vol. 38, p. 1933 - 1938
反应条件
water; barium carbonate
参考文献
Spaeth et al.
Chemische Berichte, 1935 , vol. 68, p. 699,701
