4-氟氯苄合成路线

参考文献

Beattie; Crossley; Dickinson; Dover
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 277 - 285

参考文献

Hoefnagel, A. J.; Vos, R. H. de; Wepster, B. M.
Recueil des Travaux Chimiques des Pays-Bas, 1992 , vol. 111, # 1 p. 22 - 28

371-40-44-氟苯胺+

352-11-44-氟氯苄

80143-73-3

参考文献

Pombrik, S. I.; Polunkin, E. V.; Peregudov, A. S.; Kravtsov, D. N.; Fedin, E. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 10 p. 1985 - 1987
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Melik-Ogandzhanyan, R. G.; Khachatryan, V. E.; Gapoyan, A. S.; Okhikyan, V. M.; Papoyan, S. A.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 12 p. 888 - 889
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 12 p. 1468 - 1470

352-11-44-氟氯苄+

119-36-8柳酸甲酯

851664-22-7

参考文献

Zarghi, Afshin; Tabatabai, Sayyed A.; Faizi, Mehrdad; Ahadian, Avideh; Navabi, Parisa; Zanganeh, Vahideh; Shafiee, Abbas
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1863 - 1865

864448-34-03-(4-氟苄基)-7-甲基-3,7,9-三氮杂双环[3.3.1]壬烷

参考文献

NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/103054 A2, 2005 ;
Location in patent: Page/Page column 111-112 ;
WO 2005/103054 A2

868408-05-3+

352-11-44-氟氯苄

864448-43-13-(4-氟苄基)-7-噁-3,9-二氮杂双环[3.3.1]壬烷

参考文献

NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/103054 A2, 2005 ;
Location in patent: Page/Page column 135 ;
WO 2005/103054 A2

73874-95-04-Boc-氨基哌啶+

352-11-44-氟氯苄

92539-14-51-(4-氟苄基)哌啶-4-胺

参考文献

ASTRAZENECA AB
Patent: WO2007/53082 A1, 2007 ;
Location in patent: Page/Page column 52 ;
WO 2007/053082 A1

5382-16-14-羟基哌啶+

352-11-44-氟氯苄

92539-14-51-(4-氟苄基)哌啶-4-胺

参考文献

Nisshin Flour Milling Co., Ltd.
Patent: US5736550 A1, 1998 ;

352-11-44-氟氯苄

92539-14-51-(4-氟苄基)哌啶-4-胺

参考文献

Mao, Yongjun; Lin, Nan; Tian, Wang; Han, Xiaofeng; Han, Xiaobing; Huang, Ziwei; An, Jing
Journal of Medicinal Chemistry, 2012 , vol. 55, # 3 p. 1346 - 1359