1: thien-2-yl bromide With 1,3-bis-(diphenylphosphino)propane; palladium diacetate in tetrahydrofuran T=50°C; 0.0833333 h; Inert atmosphere; 2: (4-fluoro-phenyl)-magnesium bromide in tetrahydrofuran T=60°C; 7 h; 3: With hydrogenchloride in tetrahydrofuran; water T=30°C; Cooling with ice;
参考文献
Fillers, Walter Ferdinand Maria; Broeckx, Rudy Laurent Maria; Nieste, Patrick Hubert J.; Hatsuda, Masanori; Yoshinaga, Masahiko; Yada, Mitsuhiro
Patent: US2010/99883 A1, 2010 ;
Location in patent: Page/Page column 43-44 ;
US 20100099883 A1
UNIVERSITY OF PRINCE EDWARD ISLAND; GENESIS GROUP INC.; SHAVER, Michael, P.; KOZAK, Christopher, M.
Patent: WO2013/53046 A1, 2013 ;
Location in patent: Paragraph 00282-00284 ;