4,4-二氟乙酰乙酸乙酯合成路线 （共 32 条）
参考文献
Desirant
Bulletin des Societes Chimiques Belges, 1930 , vol. 39, p. 144,155
反应条件
1: 80 percent / sodium borohydride / toluene / 4.5 h / 20 °C 2: phosphorus pentoxide / 1 h View Scheme
参考文献
PFIZER INC.; SPRINGER, John Robert; DEVADAS, Balekudru; GARLAND, Danny James; GRAPPERHAUS, Margaret Lanahan; HAN, Seungil; HOCKERMAN, Susan Landis; HUGHES, Robert Owen; SAIAH, Eddine; SCHNUTE, Mark Edward; SELNESS, Shaun Raj; WALKER, Daniel Patrick; WAN, Zhao-Kui; XING, Li; ZAPF, Christoph Wolfgang; SCHMIDT, Michelle, Ann
Patent: WO2014/68527 A1, 2014 ;
反应条件
formic acid in tert-butyl methyl ether; water T=5 - 22°C; 20 h; Product distribution / selectivity;
参考文献
BAYER CROPSCIENCE AG; PAZENOK, Sergii; MUeLLER, Michael; LUI, Norbert
Patent: WO2011/144549 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
acetic acid in water T=5 - 22°C; 20 h;
参考文献
BAYER CROPSCIENCE AG; PAZENOK, Sergii; MUeLLER, Michael; LUI, Norbert
Patent: WO2011/144549 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 60°C; 72 h; Inert atmosphere; 2: With water in tetrahydrofuran T=0°C; 0.5 h; Inert atmosphere;
参考文献
Wu, Jing-Jing; Cheng, Jian-Hang; Zhang, Jian; Shen, Li; Qian, Xu-Hong; Cao, Song
Tetrahedron, 2011 , vol. 67, # 2 p. 285 - 288
反应条件
1: acetic anhydride / 135 °C 2: sodium hydroxide / water / 1 h / 20 °C / Cooling with ice View Scheme
反应条件
1: acetic anhydride / 135 °C 2: Solkane® 365mfc / 3 h / 0 °C / Inert atmosphere View Scheme
反应条件
acetic acid in water T=5 - 22°C; 20 h;
参考文献
BAYER CROPSCIENCE AG; PAZENOK, Sergii; MUeLLER, Michael; LUI, Norbert
Patent: WO2011/144549 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With triethylamine in 1,2-dichloro-ethane
0.0166667 h;
2: With titanium tetrachloride in dichloromethane; 1,2-dichloro-ethane
T=20°C;
3: With water; sodium cyanoborohydride; sodium hydrogencarbonate
more than 3 stages;
参考文献
NOVARTIS AG
Patent: WO2008/63912 A1, 2008 ;
Location in patent: Page/Page column 73 ;
反应条件
ammonium acetate in methanol
参考文献
Merrell Toraude et Compagnie
Patent: US4435425 A1, 1984 ;
