1.1: 89 percent / toluene / Heating 2.1: aq. HCl; NaBH3CN / methanol 2.2: NaOH / H2O; diethyl ether 3.1: SiO2 / toluene / Heating View Scheme

1.1: aq. HCl; NaBH3CN / methanol 1.2: NaOH / H2O; diethyl ether 2.1: SiO2 / toluene / Heating View Scheme

1.1: Et3N; 4-dimethylaminopyridine; dicyclohexylcarbodiimide / CHCl3 / 15 h / 0 - 20 °C 2.1: 67 percent / acetone / toluene / 1.5 h / Heating 3.1: 90 percent / toluene / 1.5 h / Heating 4.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C 5.1: 80 percent / NaBH3CN / acetic acid / 5 h / 20 °C 6.1: 89 percent / toluene / Heating 7.1: aq. HCl; NaBH3CN / methanol 7.2: NaOH / H2O; diethyl ether 8.1: SiO2 / toluene / Heating View Scheme

1.1: 85 percent / Et3N; 4-dimethylaminopyridine; dicyclohexylcarbodiimide / CH2Cl2 / 15 h / 0 - 20 °C 2.1: 80 percent / NaBH3CN / acetic acid / 5 h / 20 °C 3.1: 89 percent / toluene / Heating 4.1: aq. HCl; NaBH3CN / methanol 4.2: NaOH / H2O; diethyl ether 5.1: SiO2 / toluene / Heating View Scheme

1.1: 90 percent / toluene / 1.5 h / Heating 2.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C 3.1: 80 percent / NaBH3CN / acetic acid / 5 h / 20 °C 4.1: 89 percent / toluene / Heating 5.1: aq. HCl; NaBH3CN / methanol 5.2: NaOH / H2O; diethyl ether 6.1: SiO2 / toluene / Heating View Scheme

1.1: 80 percent / NaBH3CN / acetic acid / 5 h / 20 °C 2.1: 89 percent / toluene / Heating 3.1: aq. HCl; NaBH3CN / methanol 3.2: NaOH / H2O; diethyl ether 4.1: SiO2 / toluene / Heating View Scheme

1.1: 67 percent / acetone / toluene / 1.5 h / Heating 2.1: 90 percent / toluene / 1.5 h / Heating 3.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C 4.1: 80 percent / NaBH3CN / acetic acid / 5 h / 20 °C 5.1: 89 percent / toluene / Heating 6.1: aq. HCl; NaBH3CN / methanol 6.2: NaOH / H2O; diethyl ether 7.1: SiO2 / toluene / Heating View Scheme

1.1: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C 2.1: 80 percent / NaBH3CN / acetic acid / 5 h / 20 °C 3.1: 89 percent / toluene / Heating 4.1: aq. HCl; NaBH3CN / methanol 4.2: NaOH / H2O; diethyl ether 5.1: SiO2 / toluene / Heating View Scheme