4,5-二甲氧基-1-氰基苯并环丁烷合成路线 （共 17 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-10°C; Inert atmosphere;
参考文献
RICHTER GEDEON NYRT.; UJVARI, Viktor; BODI, Jozsef; FARAGO, Janos; SZKE, Katalin; FAIGL, Ferenc; NEMET, Zoltan; TEMESVARI, Krisztina; KISS, Robert; MATRAVOeLGYI, Bela; KASSAI, Ferencne; KISS-BARTOS, Dorottya
Patent: WO2011/138625 A1, 2011 ;
Location in patent: Page/Page column 31-32 ;
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-60 - -5°C; Inert atmosphere; 2: With water in tetrahydrofuran; hexane
参考文献
LES LABORATOIRES SERVIER
Patent: US2010/160628 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in isopropyl alcohol T=65°C; 2 h;
参考文献
US2010/56778 A1, ;
Page/Page column 3 ;
反应条件
in dimethyl sulfoxide
参考文献
Schiess, Peter; Rutschmann, Suzanne; Toan, Van Vien
Tetrahedron Letters, 1982 , vol. 23, # 36 p. 3669 - 3672
反应条件
1: 100 percent / PCl5 / CCl4 2: 60 percent / 550 °C / 0.08 Torr 3: 38 percent / dimethylsulfoxide View Scheme
参考文献
Tetrahedron Letters, , vol. 23, # 36 p. 3669 - 3672
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C 2: sodium amide / ammonia / 2 h / 20 °C / |liquid NH3 View Scheme
反应条件
1: sodium tetrahydroborate; methanol; pyridine / 9 h / 100 °C 2: N-bromosuccinmide / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C 3: sodium amide / ammonia / 2 h / 20 °C / |liquid NH3 View Scheme
反应条件
1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C 2: sodium tetrahydroborate; methanol; pyridine / 9 h / 100 °C 3: N-bromosuccinmide / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C 4: sodium amide / ammonia / 2 h / 20 °C / |liquid NH3 View Scheme
反应条件
1: sodium acetate; tetrabutylammomium bromide; tris-(o-tolyl)phosphine; 5 palladium on charcoal / N,N-dimethyl acetamide / 12 h / |Reflux 2: sodium tetrahydroborate; pyridine / methanol / 9 h / |Reflux 3: bromine; sodium acetate; acetic acid 4: ammonia; sodium; anhydrous iron chloride / 2 h / 20 °C View Scheme
反应条件
1: 60 percent / 550 °C / 0.08 Torr 2: 38 percent / dimethylsulfoxide View Scheme
参考文献
Tetrahedron Letters, , vol. 23, # 36 p. 3669 - 3672
