3-氨基苯并[b]噻吩-2-羧酸甲酯合成路线 （共 8 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h; Heating / reflux;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: WO2009/48274 A2, 2009 ;
Location in patent: Page/Page column 22 ;
反应条件
water; potassium hydroxide in ethylene glycol dimethyl ether T=-5 - 0°C; 1 h; Inert atmosphere;
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Kimatrai Salvador, Maria; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Bassetto, Marcella; Brancale, Andrea; Hamel, Ernest; Castagliuolo, Ignazio; Bortolozzi, Roberta; Basso, Giuseppe; Viola, Giampietro
Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2606 - 2618
反应条件
in N-methyl-acetamide
反应条件
sodium hydride in tetrahydrofuran 6 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 20 p. 4898 - 4908
反应条件
sodium methylate in N,N-dimethyl-formamide T=60°C; 3 h;
参考文献
Synthesis, , # 8 art. no. Z54010SS, p. 1314 - 1318
反应条件
1: With tert.-butylnitrite; copper(ll) bromide in acetonitrile T=0 - 20°C; 2 h; Inert atmosphere; 2: With hydrogenchloride in water; acetonitrile Inert atmosphere;
参考文献
Iaroshenko, Viktor O.; Ali, Sajid; Mkrtchyan, Satenik; Gevorgyan, Ashot; Babar, Tariq Mahmood; Semeniuchenko, Volodymyr; Hassan, Zahid; Villinger, Alexander; Langer, Peter
Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7135 - 7139
反应条件
in 1-methyl-pyrrolidin-2-one
参考文献
Salvati, Mark E.; Balog, James Aaron; Shan, Weifang; Giese, Soren
Patent: US2003/114420 A1, 2003 ;
US 20030114420 A1
Title/Abstract Full Text Show Details
Salvati, Mark E.; Balog, James Aaron; Shan, Weifang; Giese, Soren; Harikrishnan, Lalgudi S.
Patent: US2004/77606 A1, 2004 ;
US 20040077606 A1
反应条件
in 1-methyl-pyrrolidin-2-one
参考文献
Merck Sharpe and Dohme Ltd.
Patent: US5432177 A1, 1995 ;
