2-氨基-5,6-二氟苯并噻唑合成路线 （共 3 条）
反应条件
1: in acetic acid T=0°C; 2: With bromine in acetic acid T=20°C; 1 h;
参考文献
Charris, Jaime; Monasterios, Melina; Dominguez, Josee; Infante, Wilson; Castro, Norma De
Heterocyclic Communications, 2002 , vol. 8, # 3 p. 275 - 280
参考文献
Mylari; Larson; Beyer; Zembrowski; Aldinger; Dee; Siegel; Singleton
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 108 - 122
反应条件
1: hydrazine monohydrochloride; hydrazine hydrate / ethylene glycol / 2 h / 140 °C
2: thionyl chloride / 2 h / 50 °C
View Scheme
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
