5-氨基-1,3-二甲基吡唑合成路线 （共 27 条）
反应条件
T=120°C; Michael addition;
参考文献
Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4089 - 4100
反应条件
1.1: 24 h / 20 °C 2.1: potassium hydroxide / acetone / 0.17 h / |Reflux 2.2: 1 h / |Reflux 3.1: potassium hydroxide / ethanol; water / 10 h / |Reflux View Scheme
参考文献
Maggio, Benedetta; Raffa, Demetrio; Raimondi, Maria Valeria; Daidone, Giuseppe
Molecules, 2013 , vol. 18, # 10 p. 13096 - 13110
反应条件
1: 100 percent / ZnCl2 / aq. HCl; ethanol / 1 h / Heating 2: 44 percent / sodium hydroxide, potassium permanganate / H2O / 2 h / Heating View Scheme
参考文献
Lynch; Khan; Teo; Pedrotti
Canadian Journal of Chemistry, 1988 , vol. 66, # 3 p. 420-428
反应条件
potassium carbonate; Cu(OAc)2 in hexane; N,N-dimethyl-formamide
参考文献
Cell Pathways, Inc.
Patent: US5852035 A1, 1998 ;
反应条件
Cu(OAc)2 in hexane; chloroform; N,N-dimethyl-formamide
参考文献
Sterling Winthrop Inc.
Patent: US5614530 A1, 1997 ;
反应条件
potassium carbonate; copper(I) bromide in N,N-dimethyl-formamide T=150°C; 1 h;
参考文献
Smith, Adrian L.; Thomson, Christopher G.; Leeson, Paul D.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 13 p. 1483 - 1486
反应条件
T=250°C; 0.25 h; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 47, # 14 p. 2395 - 2398
反应条件
1: 89 percent / 1 h / 120 °C 2: 77 percent / POCl3 / 18 h / 120 °C 3: 99 percent / potassium hydroxide / H2O; 1,2-dimethoxy-ethane / 18 h / 20 °C 4: SOCl2 / 1 h / 80 °C View Scheme
参考文献
Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 29 - 32
反应条件
1: 89 percent / 1 h / 120 °C 2: 77 percent / POCl3 / 18 h / 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 15 p. 4089 - 4100
反应条件
1: T=160°C; 5 h; 2: With thionyl chloride
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 7 p. 2340 - 2343
