1-Boc-4-(4-溴苯基)哌嗪合成路线 （共 11 条）
反应条件
1.1: n-BuLi / tetrahydrofuran; toluene; hexane / 0.33 h / -70 - -60 °C
1.2: triisopropyl borate / tetrahydrofuran; toluene; hexane / -70 - 0 °C
1.3: 92 percent / H3PO4; H2O / tetrahydrofuran; toluene; hexane / 0.5 h
2.1: 86 percent / HCl / ethyl acetate; dioxane / 6 h / 20 °C
3.1: NaOH
View Scheme
参考文献
Chen, Cheng-yi; Dagneau, Philippe; Grabowski, Edward J.J.; Oballa, Renata; O'Shea, Paul; Prasit, Peppi; Robichaud, Joel; Tillyer, Rich; Wang, Xin
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2633 - 2638
