3-(吡啶-4-基)-3,9-二氮杂螺[5.5]十一烷合成路线 (共 2 条)
反应条件
trifluoroacetic acid in dichloromethane
参考文献
GRUeNENTHAL GMBH; MERLA, Beatrix; OBERBOeRSCH, Stefan; REICH, Melanie; SCHUNK, Stefan; JOSTOCK, Ruth; HEES, Sabine; ENGELS, Michael; GERMANN, Tieno; BIJSTERVELD, Edward
Patent: WO2010/99938 A1, 2010 ;
Location in patent: Page/Page column 103-104 ;
反应条件
1: Pd2(dba)3; S-BINAP; t-BuONa / toluene; CHCl3 / 85 °C 2: TFA / CH2Cl2 View Scheme
参考文献
Smyth; Rose; Mehrotra; Heath; Ruhter; Schotten; Seroogy; Volkots; Pandey; Scarborough
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1289 - 1292