(1-乙氧基亚丙基)丙二腈合成路线 （共 6 条）
反应条件
in acetic anhydride 15 h; Reflux;
参考文献
KARO BIO AB; Löfstedt, Joakim; Wu, Xiongyu; Krüger, Lars
Patent: US2012/202853 A1, 2012 ;
Location in patent: Paragraph 0166; 0167 ;
参考文献
Kornuta,P.P. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1971 , vol. 41, p. 2390 - 2395,2416 - 2421
反应条件
sodium hydroxide; hydroxylamine hydrochloride
参考文献
Taylor,E.C.; Garcia,E.E.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120
反应条件
sodium ethanolate
1.) EtOH, 15 min, 2.) 1 h; Yield given. Multistep reaction;
参考文献
Sundoro, Boby; Chang, Chai-Yan; Aslanian, Robert; Jordan, Frank
Synthesis, 1983 , # 7 p. 555 - 556
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
反应条件
1: ethanol / Heating
2: H2O / 24 h / Heating
3: POCl3; DMF / 4 h / Heating
View Scheme
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
