Boc-1-氨基环戊烷羧酸合成路线 （共 10 条）
反应条件
sodium hydroxide in water; acetone Inert atmosphere;
参考文献
Fustero, Santos; Rodrigo, Vanessa; Sanchez-Rosello, Maria; Del Pozo, Carlos; Timoneda, Joaquin; Frizler, Maxim; Sisay, Mihiret T.; Bajorath, Juergen; Calle, Luis P.; Canada, F. Javier; Jimenez-Barbero, Jesas; Guetschow, Michael
Chemistry - A European Journal, 2011 , vol. 17, # 19 p. 5256 - 5260
反应条件
1: 1-aminocyclopentane carboxylic acid With tetreamethyl ammonium hydroxide in acetonitrile T=20°C; 2: di-tert-butyl dicarbonate in acetonitrile 96 h; 3: With citric acid in water pH=3 - 4;
参考文献
UNIVERSITY OF WOLLONGONG
Patent: WO2006/74501 A1, 2006 ;
Location in patent: Page/Page column 81 ;
反应条件
in water; ethyl acetate; acetonitrile
参考文献
Centre National de la Recherche Scientifique (CNRS); Universite Louis Pasteur
Patent: US7745413 B2, 2010 ;
反应条件
hydrogenchloride in tetrahydrofuran
反应条件
triethylamine in water; acetone 4 h;
参考文献
WO2005/44810 A1, ;
Page/Page column 105 ;
WO 2005/044810 A1
反应条件
triethylamine in water
参考文献
Pfizer, Inc.
Patent: US5270331 A1, 1993 ;
反应条件
1: 71 percent / Ba(OH)2*8H2O / H2O / 3 h / Heating 2: 39 percent / aq. NaOH / 2-methyl-propan-2-ol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 36, # 3 p. 265 - 286
反应条件
1: 64 percent / (NH4)2CO3 / ethanol; H2O / 2 h / 58 - 60 °C 2: 71 percent / Ba(OH)2*8H2O / H2O / 3 h / Heating 3: 39 percent / aq. NaOH / 2-methyl-propan-2-ol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 36, # 3 p. 265 - 286
反应条件
sodium hydroxide; magnesium oxide
参考文献
Journal of medicinal chemistry, , vol. 14, # 10 p. 904 - 906
反应条件
1: potassium carbonate / acetone / Reflux
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Bremner, John B.; Keller, Paul A.; Pyne, Stephen G.; Robertson, Mark J.; Sakthivel; Somphol, Kittiya; Baylis, Dean; Coates, Jonathan A.; Deadman, John; Jeevarajah, Dharshini; Rhodes, David I.
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1265 - 1270
