2,4-二羟基-6-甲基-噻吩并[3,2-d]嘧啶合成路线 （共 3 条）
反应条件
potassium hydroxide in ethanol T=80°C; 3 h; Heating / reflux;
参考文献
Nihon Nohyaku Co., Ltd.
Patent: EP1544202 A1, 2005 ;
Location in patent: Page/Page column 49 ;
反应条件
1: T=180°C; 2.5 h; 2: With sodium hydroxide; water 3: With acetic acid in water
参考文献
Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP2003131 A1, 2008 ;
Location in patent: Page/Page column 64 ;
EP 2003131 A1
反应条件
trichlorophosphate in DMF (N,N-dimethyl-formamide) T=100°C; 2 h; Heating / reflux;
参考文献
Nihon Nohyaku Co., Ltd.
Patent: EP1544202 A1, 2005 ;
Location in patent: Page/Page column 49 ;
