7-甲基-噻吩并[3,2-d]嘧啶-2,4(1h,3h)-二酮合成路线 （共 10 条）
反应条件
urea in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl-formamide
参考文献
NAKASHIMA, YOSHIHARU; FUJITA, TAKASHI; HIZUKA, MICHIYO; IKAWA, HIROSHI; HIRUMA, TORU
Patent: US2001/6969 A1, 2001 ;
反应条件
1: in acetonitrile 0.25 h; 2: With ammonia in methanol T=70°C; 0.25 h;
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
Location in patent: Page/Page column 67 ;
US 20120015962 A1
反应条件
1: With acetic acid in water T=20°C; 2: With water; sodium hydroxide T=130°C; 4 h; 3: With hydrogenchloride in water pH=6;
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
Location in patent: Page/Page column 108 ;
US 20120015962 A1
反应条件
1: With methanol; sodium hydroxide; water 2 h; Heating / reflux; 2: With hydrogenchloride in methanol; water
参考文献
PIRAMED LIMITED
Patent: WO2007/122410 A1, 2007 ;
Location in patent: Page/Page column 87-88 ;
反应条件
in N,N-dimethyl-formamide 2.5 h; Heating / reflux;
参考文献
Fujirebio Inc.
Patent: US6339089 B2, 2002 ;
Location in patent: Referential example 16 ;
反应条件
sodium hydroxide 2 h; Yield given;
参考文献
Jourdan; Laduree; Robba
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 2 p. 305 - 312
反应条件
trichlorophosphate in water; N,N-dimethyl-aniline; acetonitrile
参考文献
Genentech, Inc.; Babu, Srinivasan; Cheng, Zhigang; Gosselin, Francis; Hidber, Pirmin; Hoffmann, Ursula; Humphries, Theresa; Reents, Reinhard; Tian, Qingping; Yajima, Herbert
Patent: US2014/100366 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: trichlorophosphate / water; N,N-dimethyl-aniline; acetonitrile 2: methanol View Scheme
参考文献
Genentech, Inc.; Babu, Srinivasan; Cheng, Zhigang; Gosselin, Francis; Hidber, Pirmin; Hoffmann, Ursula; Humphries, Theresa; Reents, Reinhard; Tian, Qingping; Yajima, Herbert
Patent: US2014/100366 A1, 2014 ;
反应条件
1.1: trichlorophosphate / 0.25 h / 180 °C / microwave 2.1: hydrogen; sodium acetate / 20 palladium(II) hydroxide on carbon / ethyl acetate; isopropyl alcohol / 2585.81 Torr 3.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 1 h / Reflux 3.2: 0.5 h / 100 °C View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1.1: trichlorophosphate / 0.25 h / 180 °C / microwave 2.1: hydrogen; sodium acetate / 20 palladium(II) hydroxide on carbon / ethyl acetate; isopropyl alcohol / 2585.81 Torr 3.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 1 h / Reflux 3.2: 0.5 h / 100 °C 4.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 1 h View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
