2,4-二氯-7-甲基噻吩并[3,2-d]嘧啶合成路线 (共 6 条)
反应条件
trichlorophosphate in water; N,N-dimethyl-aniline; acetonitrile
参考文献
Genentech, Inc.; Babu, Srinivasan; Cheng, Zhigang; Gosselin, Francis; Hidber, Pirmin; Hoffmann, Ursula; Humphries, Theresa; Reents, Reinhard; Tian, Qingping; Yajima, Herbert
Patent: US2014/100366 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: T=200°C; 4 h; 2: With trichlorophosphate in acetonitrile 24 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2408 - 2411
反应条件
1.1: acetonitrile / 0.25 h 1.2: 0.25 h / 70 °C 2.1: trichlorophosphate / 0.25 h / 180 °C / microwave View Scheme
参考文献
US2012/15962 A1, ;
US 20120015962 A1
参考文献
Genentech, Inc.; Babu, Srinivasan; Cheng, Zhigang; Gosselin, Francis; Hidber, Pirmin; Hoffmann, Ursula; Humphries, Theresa; Reents, Reinhard; Tian, Qingping; Yajima, Herbert
Patent: US2014/100366 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1.1: hydrogen; sodium acetate / 20 palladium(II) hydroxide on carbon / ethyl acetate; isopropyl alcohol / 2585.81 Torr 2.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 1 h / Reflux 2.2: 0.5 h / 100 °C View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1.1: hydrogen; sodium acetate / 20 palladium(II) hydroxide on carbon / ethyl acetate; isopropyl alcohol / 2585.81 Torr 2.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 1 h / Reflux 2.2: 0.5 h / 100 °C 3.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 1 h View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1