2-氯-7-甲基-4-(4-吗啉基)噻吩并[3,2-d]嘧啶合成路线 （共 4 条）
参考文献
Genentech, Inc.; Babu, Srinivasan; Cheng, Zhigang; Gosselin, Francis; Hidber, Pirmin; Hoffmann, Ursula; Humphries, Theresa; Reents, Reinhard; Tian, Qingping; Yajima, Herbert
Patent: US2014/100366 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: sodium hydroxide; potassium cyanate; acetic acid / water 2: trichlorophosphate / water; N,N-dimethyl-aniline; acetonitrile 3: methanol View Scheme
参考文献
Genentech, Inc.; Babu, Srinivasan; Cheng, Zhigang; Gosselin, Francis; Hidber, Pirmin; Hoffmann, Ursula; Humphries, Theresa; Reents, Reinhard; Tian, Qingping; Yajima, Herbert
Patent: US2014/100366 A1, 2014 ;
反应条件
1: trichlorophosphate / water; N,N-dimethyl-aniline; acetonitrile 2: methanol View Scheme
参考文献
Genentech, Inc.; Babu, Srinivasan; Cheng, Zhigang; Gosselin, Francis; Hidber, Pirmin; Hoffmann, Ursula; Humphries, Theresa; Reents, Reinhard; Tian, Qingping; Yajima, Herbert
Patent: US2014/100366 A1, 2014 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -40 °C 1.2: 2 h / -40 °C 1.3: 1 h / Cooling with ice 2.1: acetic acid / 1,2-dichloro-ethane / 0.25 h 2.2: 24 h / 20 °C 3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; acetonitrile / 0.2 h / 140 °C / Microwave irradiation 4.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 25 °C 5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 21 p. 7579 - 7587
