1: piperidine / pyridine / 110 - 130 °C 2: SOCl2, DMF View Scheme

thionyl chloride; N,N-dimethyl-formamide

1: Heating 2: H2 / Pd/C / tetrahydrofuran / 40 - 50 °C 3: LiAlH4 / tetrahydrofuran / 50 - 60 °C 4: HBr / 120 - 130 °C View Scheme

2: H2 / Pd/C 3: aq. KOH View Scheme

1: Heating 2: H2 / Pd/C / tetrahydrofuran / 40 - 50 °C 3: LiAlH4 / tetrahydrofuran / 50 - 60 °C 4: HBr / 120 - 130 °C 5: 1) lithium diisopropylamide / 1) hexane, THF, 50 deg C, 2.5 h, 2) THF, a) r.t., 2 h, b) 40 deg C, 1 h 6: PCl5 / 6 h / Ambient temperature 7: 75 percent / diethyl ether / 12 h / 0 °C View Scheme

暂无反应条件数据

2: H2 / Pd/C View Scheme