1-(4-噻吩-2-苯基)-乙酮合成路线 （共 23 条）
反应条件
potassium phosphate; Cl2Ni(1,2-bis(diphenylphosphino)ethane); triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; zinc in 1,4-dioxane; water T=50°C;
参考文献
Galland, Jean-Christophe; Savignac, Monique; Genet, Jean-Pierre
Tetrahedron Letters, 1999 , vol. 40, # 12 p. 2323 - 2326
反应条件
1: 2-(triethoxysilyl)thiophene With indium(III) chloride; tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 1 h; 2: 4'-iodoacetophenone With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 14 h; Reflux;
参考文献
Font-Sanchis, Enrique; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Dalton Transactions, 2009 , # 14 p. 2470 - 2473
反应条件
catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; 1 h;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 48 p. 12939 - 12941
反应条件
tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; silver(l) oxide in tetrahydrofuran T=90°C; Hiyama-type coupling; 1 h;
参考文献
Napier, Spencer; Marcuccio, Sebastian M.; Tye, Heather; Whittaker, Mark
Tetrahedron Letters, 2008 , vol. 49, # 24 p. 3939 - 3942
反应条件
1: 1-(4-(triethoxysilyl)phenyl)ethanone With indium(III) chloride; tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.5 h; 2: 2-Iodothiophene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 14 h; Reflux;
参考文献
Font-Sanchis, Enrique; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Dalton Transactions, 2009 , # 14 p. 2470 - 2473
反应条件
palladium diacetate T=100°C; Stille cross-coupling; 15 h; Ionic liquid;
参考文献
Louaisil, Nicolas; Pham, Phuoc Dien; Boeda, Fabien; Faye, Djibril; Castanet, Anne-Sophie; Legoupy, Stephanie
European Journal of Organic Chemistry, 2011 , # 1 p. 143 - 149
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=25°C; 16 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 2 h; RefluxInert atmosphere;
参考文献
Kourounakis, Angeliki P.; Charitos, Christos; Rekka, Eleni A.; Kourounakis, Panos N.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 18 p. 5861 - 5865
反应条件
tetrakis(triphenylphosphine) palladium(0); cesium fluoride in 1,2-dichloro-ethane T=75°C; 6 h; Inert atmosphereSealed tube;
参考文献
Ramgren, Stephen D.; Garg, Neil K.
Organic Letters, 2014 , vol. 16, # 3 p. 824 - 827
反应条件
tetra-(n-butyl)ammonium iodide; (Ph3P)2Pd(Ph)(I) in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; 1.5 h;
参考文献
Bumagin, N. A.; Kalinovskii, I. O.; Beletskaya, I. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1159 - 1162
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1467 - 1470
