1-(4-噻吩-2-苯基)-乙酮合成路线 （共 23 条）
反应条件
1: thiophen-2-yl-MgX, X = halide With zinc(II) chloride in tetrahydrofuran T=25°C; 0.25 h; Inert atmosphere; 2: para-bromoacetophenone With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
C34H38Cl2N4Pd; caesium carbonate in 1,4-dioxane T=100°C; Suzuki coupling; 25 h;
参考文献
Morgan, Brad P.; Galdamez, Gabriela A.; Gilliard Jr., Robert J.; Smith, Rhett C.
Dalton Transactions, 2009 , # 11 p. 2020 - 2028
反应条件
bromine in chloroform T=20°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 18 p. 5861 - 5865
