2-碘-1,1,1-三氟乙烷合成路线 （共 59 条）
反应条件
copper in dimethyl sulfoxide T=120°C; 55 h; Schlenk techniqueInert atmosphereSealed tube;
参考文献
Organic Letters, , vol. 16, # 9 p. 2306 - 2309
反应条件
1: With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=20°C; 0.0166667 h; Inert atmosphere; 2: With water in 1,4-dioxane T=80°C; 12 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 4 p. 1033 - 1036
反应条件
in N-methyl-acetamide; water
参考文献
Sumitomo Chemical Company, Limited
Patent: US4202895 A1, 1980 ;
反应条件
2,2'-azo-bisisobutyronitrile
1.) 85 deg C, 15 h, 2.) DMF, 0 deg C, 3 h to r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Cloux; Kovats
Synthesis, 1992 , # 4 p. 409 - 412
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
Molecules, 2009 , vol. 14, # 2 p. 777 - 784
反应条件
copper in N,N-dimethyl-formamide
T=190°C;
参考文献
McLoughlin,V.C.R.; Thrower,J.
Tetrahedron, 1969 , vol. 25, p. 5921 - 5940
反应条件
tris-(dibenzylideneacetone)dipalladium(0); water; cesium fluoride; copper(l) chloride; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in N,N-dimethyl-formamide
T=65°C; 16 h; Inert atmosphere;
参考文献
Liang, Apeng; Li, Xinjian; Liu, Dongfeng; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Chemical Communications, 2012 , vol. 48, # 66 p. 8273 - 8275
反应条件
potassium hydroxide in methanol
1 h; Heating;
参考文献
Trachsel, Daniel
Helvetica Chimica Acta, 2003 , vol. 86, # 7 p. 2610 - 2619
反应条件
sodium methylate in methanol
参考文献
Pinson,R. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 491 - 503
反应条件
T=100 - 170°C; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/821 A1, 2005 ;
Location in patent: Page 68 ;
WO 2005/000821 A1
