2-甲基-4,5,6,7-四氢-1H-吲哚-4-酮合成路线 （共 12 条）
反应条件
1: With potassium hydroxide; chloroacetone in methanol 7 h; Heating / reflux; 2: With ammonium acetate in methanol; water T=20°C; 2 h; Heating / reflux;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1367050 A1, 2003 ;
Location in patent: Page 10 ;
反应条件
ammonium acetate; acetic acid T=60°C; 2 h;
参考文献
Barraja, Paola; Diana, Patrizia; Montalbano, Alessandra; Carbone, Anna; Cirrincione, Girolamo; Viola, Giampietro; Salvador, Alessia; Vedaldi, Daniela; Dall'Acqua, Francesco
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9668 - 9683
反应条件
1: With toluene-4-sulfonic acid in toluene T=80°C; 2 h; 2: With sodium hydroxide in toluene T=25°C; pH=11;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1367050 A1, 2003 ;
Location in patent: Page 11-12 ;
反应条件
1: With potassium hydroxide; ammonium acetate in methanol 7 h; Heating / reflux; 2: With ammonium acetate in methanol T=20°C; 2 h; Heating / reflux; 3: With sodium hydroxide; 1,1-dimethoxyethane more than 3 stages;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1367050 A1, 2003 ;
Location in patent: Page 10 ;
反应条件
1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium(0); lt;3THF*Mg2Cl2O*TiNCOgt; T=100°C; 12 h;
参考文献
Mori, Miwako; Uozumi, Yasuhiro; Shibasaki, Masakatsu
Heterocycles, 1992 , vol. 33, # 2 p. 819 - 830
反应条件
chloro-trimethyl-silane; titanium tetrachloride; lithium; cesium fluoride in tetrahydrofuran 24 h; Heating;
参考文献
Mori, Miwako; Akashi, Masaya; Hori, Masanori; Hori, Katsutoshi; Nishida, Mayumi; Sato, Yoshihiro
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 9 p. 1655 - 1670
反应条件
1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium(0); lt;3THF*Mg2Cl2O*TiNCOgt; T=100°C; 12 h;
参考文献
Mori, Miwako; Uozumi, Yasuhiro; Shibasaki, Masakatsu
Heterocycles, 1992 , vol. 33, # 2 p. 819 - 830
反应条件
T=190 - 200°C; 0.0833333 h;
参考文献
Yuste, Francisco; Sanchez-Obregon, Ruben
Journal of Organic Chemistry, 1982 , vol. 47, # 19 p. 3665 - 3668
反应条件
potassium carbonate in 1,4-dioxane 6 h; Heating;
参考文献
Nitta; Soeda; Iino
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 932 - 934
反应条件
1: 95 percent / benzene / 4 h 2: 39 percent / potassium carbonate / dioxane / 6 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 3 p. 932 - 934
