(R)-(-)-2-氨基-1-丙醇合成路线 （共 32 条）
反应条件
in dichloromethane T=0 - 20°C; 1 h;
参考文献
Juntunen, Juha; Huuskonen, Juhani; Laine, Krista; Niemi, Riku; Taipale, Hannu; Nevalainen, Tapio; Pate, David W.; Jaervinen, Tomi
European Journal of Pharmaceutical Sciences, 2003 , vol. 19, # 1 p. 37 - 43
反应条件
sulfonic-acid-functionalized silica in dichloromethane T=20°C; 0.166667 h;
参考文献
Das, Biswanath; Venkateswarlu, Katta; Krishnaiah, Maddeboina; Holla, Harish
Tetrahedron Letters, 2006 , vol. 47, # 43 p. 7551 - 7556
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 24 h; Inert atmosphereCooling;
参考文献
Jin, Wei; Li, Xincheng; Wan, Boshun
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 484 - 491
反应条件
sulfonic-acid-functionalized silica in dichloromethane T=20°C; 0.166667 h;
参考文献
Das, Biswanath; Venkateswarlu, Katta; Krishnaiah, Maddeboina; Holla, Harish
Tetrahedron Letters, 2006 , vol. 47, # 43 p. 7551 - 7556
反应条件
1: (2R)-2-amino-1-propanol With sodium hydride in tetrahydrofuran T=20°C; 0.583333 h; 2: 2-chloro-1-ethanol acetate in tetrahydrofuran T=20°C; 18 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 149 ;
反应条件
triethylamine in toluene
20 h; Reflux;
参考文献
Harris, III, Ralph New; Repke, David Bruce; Walker, Keith A.M.
Patent: US2012/157494 A1, 2012 ;
Location in patent: Page/Page column 27-28 ;
US 20120157494 A1
反应条件
sodium carbonate in tetrahydrofuran
24 h; Ambient temperature; Yield given;
参考文献
Grote, Christopher W.; Kim, Dong Jin; Rapoport, Henry
Journal of Organic Chemistry, 1995 , vol. 60, # 21 p. 6987 - 6997
反应条件
iodine; sodium hydride
1.) THF, room temperature, 0.5 h, 2.) room temperature, overnight, 3.) 2 h; Yield givenMultistep reaction;
参考文献
Loughhead, David G.; Flippin, Lee A.; Weikert, Robert J.
Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 3373 - 3375
反应条件
copper(l) iodide; caesium carbonate in N-valeronitrile
T=125°C; 16 h;
参考文献
Shen, Hong C.; Taggart, Andrew K.P.; Wilsie, Larissa C.; Waters, M. Gerard; Hammond, Milton L.; Tata, James R.; Colletti, Steven L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 4948 - 4951
反应条件
potassium carbonate in acetonitrile
T=0 - 20°C;
参考文献
Chong, Hyun-Soon; Chen, Yunwei
Organic Letters, 2013 , vol. 15, # 23 p. 5912 - 5915
