乙基4-(4-甲氧基苯基)-2,4-二氧代丁酸酯合成路线 （共 13 条）
反应条件
1: 1-(4-methoxyphenyl)ethanone With sodium in ethanol T=20°C; 0.5 h; 2: oxalic acid diethyl ester T=20 - 80°C; 3 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1719756 A1, 2006 ;
Location in patent: Page/Page column 40 ;
EP 1719756 A1
反应条件
ethanol; sodium T=20°C; Condensation; 12 h;
参考文献
Crane, Jonathan D.; Fox, O. Danny; Sinn, Ekkehard
Journal of the Chemical Society - Dalton Transactions, 1999 , # 9 p. 1461 - 1465
参考文献
Ungoren, Sevket Hakan
Synthetic Communications, 2009 , vol. 39, # 20 p. 3657 - 3662
反应条件
1: hydroxylamine hydrochloride / ethanol / 6 h / Reflux 2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 4 h / 0 °C View Scheme
参考文献
Akbarzadeh, Tahmineh; Rafinejad, Ali; Mollaghasem, Javad Malekian; Safavi, Maliheh; Fallah-Tafti, Asal; Pordeli, Mahboobeh; Ardestani, Sussan Kabudanian; Shafiee, Abbas; Foroumadi, Alireza
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 386 - 392
反应条件
1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 2: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice 3: manganese(IV) oxide / chloroform / 24 h / 20 °C View Scheme
参考文献
Akbarzadeh, Tahmineh; Rafinejad, Ali; Mollaghasem, Javad Malekian; Safavi, Maliheh; Fallah-Tafti, Asal; Pordeli, Mahboobeh; Ardestani, Sussan Kabudanian; Shafiee, Abbas; Foroumadi, Alireza
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 386 - 392
反应条件
1: aq. sodium hydroxide,; hydrazinium sulfate / 6 h 2: 93 percent / aq. potassium hydroxide / 2 h / Heating View Scheme
参考文献
Crane, Jonathan D.; Fox, O. Danny; Sinn, Ekkehard
Journal of the Chemical Society - Dalton Transactions, 1999 , # 9 p. 1461 - 1465
反应条件
1: 2.) NaOH / 1.) water, reflux, 5 min, room temp., 2 h; 2.) water, reflux, 15 min
2: 62 percent / phosphorus pentasulfide / pyridine / 3 h / Heating
3: 1.) sodium methoxide; / 1.) methanol; 2.) room temp., overnight
View Scheme
参考文献
Ibrahim, Yehia A.; Abdel-Hady, S. A. L.; Badawy, M. A.; Ghazala, M. A. H.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 913 - 915
反应条件
1: 2.) NaOH / 1.) water, reflux, 5 min, room temp., 2 h; 2.) water, reflux, 15 min
2: 62 percent / phosphorus pentasulfide / pyridine / 3 h / Heating
View Scheme
参考文献
Eid, M. M.; Badawy, M. A.; Ghazala, M. A. H.; Ibrahim, Yehia A.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1709 - 1711
反应条件
hydroxylamine hydrochloride in ethanol
6 h; Reflux;
参考文献
Akbarzadeh, Tahmineh; Rafinejad, Ali; Mollaghasem, Javad Malekian; Safavi, Maliheh; Fallah-Tafti, Asal; Pordeli, Mahboobeh; Ardestani, Sussan Kabudanian; Shafiee, Abbas; Foroumadi, Alireza
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 386 - 392
反应条件
sodium hydroxide; sulfuric acid in water
T=20°C;
参考文献
Braga, Remi; Hecquet, Laurence; Blonski, Casimir
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2965 - 2972
