乙基4-(4-甲氧基苯基)-2,4-二氧代丁酸酯合成路线 （共 13 条）
反应条件
in ethanol
T=80°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/49578 A1, 2005 ;
Location in patent: Page/Page column 138 ;
WO 2005/049578 A1
反应条件
1: hydroxylamine hydrochloride / ethanol / 6 h / Reflux
2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 4 h / 0 °C
View Scheme
参考文献
Lopopolo, Gianfranco; Fiorella, Filomena; De Candia, Modesto; Nicolotti, Orazio; Martel, Sophie; Carrupt, Pierre-Alain; Altomare, Cosimo
European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 3 p. 180 - 191
反应条件
1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux
2: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice
3: manganese(IV) oxide / chloroform / 24 h / 20 °C
View Scheme
参考文献
Akbarzadeh, Tahmineh; Rafinejad, Ali; Mollaghasem, Javad Malekian; Safavi, Maliheh; Fallah-Tafti, Asal; Pordeli, Mahboobeh; Ardestani, Sussan Kabudanian; Shafiee, Abbas; Foroumadi, Alireza
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 386 - 392
