5-(4-溴苯基)-5-氧代戊酸合成路线 （共 10 条）
反应条件
sodium hydroxide in methanol Hydrolysis; 1.5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 10 p. 2049 - 2063
反应条件
1: AlCl3 / 3.5 h / 20 °C 2: 2 N aq. NaOH / methanol / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 10 p. 2049 - 2063
反应条件
1: AlCl3 / 3.5 h / 20 °C 2: 2 N aq. NaOH / methanol / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 10 p. 2049 - 2063
反应条件
1.1: AlCl3, aluminium chloride / 0.5 h / 0 °C / |Inert atmosphere 1.2: 1 h / 0 - 20 °C / |Inert atmosphere 2.1: sodium hydroxide / methanol / 6 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 12, # 1 p. 177 - 186
反应条件
sodium hydroxide in methanol 6 h; RefluxInert atmosphere;
参考文献
Junker, Anna; Schepmann, Dirk; Yamaguchi, Junichiro; Itami, Kenichiro; Faust, Andreas; Kopka, Klaus; Wagner, Stefan; Wuensch, Bernhard
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 177 - 186
反应条件
aluminium trichloride T=20 - 65°C;
参考文献
Heterocycles, , vol. 65, # 3 p. 649 - 656
反应条件
1.1: AlCl3, aluminium chloride / 2 h / 20 °C / Cooling with ice 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C / Cooling with ice 2.2: 18 h / 20 °C / Cooling with ice View Scheme
反应条件
hydrazine hydrate; potassium hydroxide in 1,2-bis-(2-hydroxyethoxy)-ethane T=200°C; Wolff-Kishner Reduction; Dean-StarkInert atmosphere;
参考文献
Junker, Anna; Schepmann, Dirk; Yamaguchi, Junichiro; Itami, Kenichiro; Faust, Andreas; Kopka, Klaus; Wagner, Stefan; Wuensch, Bernhard
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 177 - 186
反应条件
1: 73 percent / triethylsilane; TFA / 48 h / 55 °C
2: 67 percent / polyphosphoric acid / 12 h / 100 °C
View Scheme
参考文献
Junker, Anna; Schepmann, Dirk; Yamaguchi, Junichiro; Itami, Kenichiro; Faust, Andreas; Kopka, Klaus; Wagner, Stefan; Wuensch, Bernhard
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 177 - 186
反应条件
1: 73 percent / triethylsilane; TFA / 48 h / 55 °C
2: 67 percent / polyphosphoric acid / 12 h / 100 °C
3: 98 percent / tetrakis(triphenylphosphine)palladium; 2 M aq. K2CO3 / ethanol; toluene / Heating
View Scheme
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
