4-(苯甲酰基氨基)丁酸合成路线 （共 10 条）
反应条件
sodium hydroxide in water T=0 - 20°C; Inert atmosphere;
参考文献
UNIVERSITY OF CONNECTICUT; BALUNAS, Marcy J.; PAVLIK, Christopher M.; GERWICK, William H.
Patent: WO2014/18913 A2, 2014 ;
Location in patent: Page/Page column 46 ;
反应条件
2,6-dichloropyridine-N-oxide; dichloro(5,10,15,20-tetramesitylporphyrinato)ruthenium(IV) in benzene T=40°C;
参考文献
Ito, Rina; Umezawa, Naoki; Higuchi, Tsunehiko
Journal of the American Chemical Society, 2005 , vol. 127, # 3 p. 834 - 835
反应条件
ruthenium(IV) oxide; sodium periodate in tert-butyl alcohol T=20°C; 5 h;
参考文献
Kaname, Mamoru; Yoshifuji, Shigeyuki; Sashida, Haruki
Tetrahedron Letters, 2008 , vol. 49, # 17 p. 2786 - 2788
反应条件
1: n-buthyl-lithium, lithium naphthalenide / tetrahydrofuran; diethyl ether / 4 h / -50 - -30 °C 2: H2O / -78 - 20 °C View Scheme
参考文献
Barluenga, Jose; Foubelo, Francisco; Fananas, Francisco J.; Yus, Miguel
Tetrahedron, 1989 , vol. 45, # 7 p. 2183 - 2192
参考文献
Ruhrchemie A.G.
Patent: US2702820 , 1953 ;
Full Text Show Details
Ruhrchemie A.G.
Patent: DE932013 , 1952 ;
反应条件
water T=-78 - 20°C; Yield given;
参考文献
Barluenga, Jose; Foubelo, Francisco; Fananas, Francisco J.; Yus, Miguel
Tetrahedron, 1989 , vol. 45, # 7 p. 2183 - 2192
反应条件
sodium hydroxide; sulfuric acid 1.) water, reflux, 2h; Yield given. Multistep reaction;
参考文献
Schirmann, Peter J.; Matthews, Richard S.; Dittmer, Donald C.
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4426 - 4427
参考文献
Otsubo, Teruyuki; Matsukawa, Chiyoko; Ishizuka, Tadao; Kunieda, Takehisa
Heterocycles, 1992 , vol. 33, # 1 p. 131 - 134
反应条件
1: 59 percent / polyphosphoric acid / 0.42 h / 80 - 85 °C
2: 83 percent / sodium tetrahydroborate / CHCl3; ethanol / 1.5 h / 35 - 40 °C
3: 36 percent / phosphorus oxychloride / various solvent(s) / 12 h / Heating
View Scheme
参考文献
Browne, Elaine J.; Skelton, Brian W.; White, Allan H.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 897 - 904
反应条件
rat cecal content
T=37°C; pH=6.8; aq. phosphate buffer;
参考文献
Kong, Hyesik; Kim, Hyunjeong; Do, Heejeong; Lee, Yonghyun; Hong, Sungchae; Yoon, Jeong-Hyun; Jung, Yunjin; Kim, Young Mi
Biopharmaceutics and Drug Disposition, 2011 , vol. 32, # 6 p. 343 - 354
