顺-2-甲基-7-十八烯合成路线 （共 56 条）
反应条件
1.1: Br2 / dioxane; CH2Cl2; diethyl ether 2.1: Mg / diethyl ether 2.2: diethyl ether 3.1: NaI / dimethylformamide; acetone / 20 h / Heating View Scheme
参考文献
Kel'in; Kulinkovich
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 10 p. 1446 - 1448
反应条件
1.1: Mg / diethyl ether 1.2: diethyl ether 2.1: NaI / dimethylformamide; acetone / 20 h / Heating View Scheme
参考文献
Kel'in; Kulinkovich
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 10 p. 1446 - 1448
反应条件
1: CuBr*Me2S / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / -78 °C 2: H2O, H+ / 0.08 h 3: 1.) sodium hexamethyldisilazide / 1.) THF, reflux, 2 h, 2.) THF, a) -78 deg C, 2 h, b) RT, 12 h View Scheme
参考文献
Pikul, Stanislaw; Raczko, Jerzy; Jurczak, Janusz
Bulletin of the Polish Academy of Sciences, Chemistry, 1987 , vol. 35, # 7-8 p. 297 - 299
反应条件
1: 90 percent / PBr3 / diethyl ether / 1) overnight, 2) reflux, 2 h 2: 1) Mg, 2) HMPA / 1) THF, 2) THF, r.t., overnight View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Kumari, Sarla; Vohra, Neelam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 860 - 861
反应条件
1: 90 percent / NEt3 / CH2Cl2 / 0 °C 2: 1) Mg, 2) HMPA / 1) THF, 2) THF, r.t., overnight View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Kumari, Sarla; Vohra, Neelam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 860 - 861
反应条件
1: 88 percent / NaI / acetonitrile / 25 h / Heating 2: 61 percent / potassium tert-butoxide / tetrahydrofuran / 1 h / -10 °C View Scheme
参考文献
Ujvary, Istvan; Voigt, Erzsebet; Lesko, Katalin
Acta Chimica Hungarica, 1988 , vol. 125, # 1 p. 131 - 140
反应条件
1.1: C32H41N3O4Ru / tetrahydrofuran / 6 h / 35 °C / |Inert atmosphere; |Glovebox 2.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / |Inert atmosphere 2.2: 4 h / 0 - 20 °C / |Inert atmosphere 3.1: tetrahydrofuran / |Inert atmosphere 3.2: -78 - 20 °C / |Inert atmosphere View Scheme
参考文献
Herbert, Myles B.; Marx, Vanessa M.; Pederson, Richard L.; Grubbs, Robert H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 1 p. 310 - 314
Angew. Chem., 2012 , vol. 125, # 1 p. 328 - 332,5
反应条件
bis(cyclopentadienyl)titanium dichloride; magnesium in tetrahydrofuran 12 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Schobert, Rainer
Angewandte Chemie, 1988 , vol. 100, # 6 p. 869 - 871
反应条件
sodium iodide in N,N-dimethyl-formamide T=130°C; 24 h; Product distribution;
参考文献
Sonnet, Philip E.
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 154 - 157
反应条件
sodium iodide in N,N-dimethyl-formamide T=90°C; 24 h; Product distribution;
参考文献
Sonnet, Philip E.
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 154 - 157
