6H-噻吩并[2,3-b]吡咯-5-羧酸乙酯合成路线 （共 7 条）
反应条件
in xylene 0.166667 h; Heating;
参考文献
Eras, J.; Galvez, C.; Garcia, F.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 215 - 217
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
1: NaOEt / ethanol / 2 h / 0 - 20 °C 2: 1.2 g / xylene / 145 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 26 p. 8289 - 8298
反应条件
N-chloro-succinimide; acetic acid in chloroform T=20°C;
参考文献
Cai, Hui; Carruthers, Nicholas I.; Dvorak, Curt A.; Edwards, James P.; Kwok, Annette K.
Patent: US2004/48878 A1, 2004 ;
Location in patent: Page/Page column 9 ;
US 20040048878 A1
反应条件
N-chloro-succinimide in diethyl ether; chloroform; acetic acid; Petroleum ether
参考文献
Pfizer Inc.
Patent: US6399601 B1, 2002 ;
反应条件
1: KOH / H2O / 3 h / Heating 2: Cu / quinoline / 1.5 h / 150 °C View Scheme
参考文献
Farnier,M. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1973 , vol. 277, p. 1149 - 1151
反应条件
1: With sodium hydroxide; ethanol; water
1 h; Heating / reflux;
2: With hydrogenchloride; water in ethanol
T=20°C; 0.5 h;
参考文献
Keio University
Patent: EP2022794 A1, 2009 ;
Location in patent: Page/Page column 18; 19 ;
