1-氧杂环十五烷-2-酮合成路线 （共 40 条）
反应条件
oxygen; toluene-4-sulfonic acid; Sensitox in dichloromethane 0.5 h; Irradiationinvestigation of the photooxygenation of the hydroxy oxazoles; Product distribution;
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron, 1981 , vol. 37, # 23 p. 4059 - 4067
反应条件
in tetrachloromethane 12 h; Heating;
参考文献
Torra, Nuria; Urpi, Felix; Vilarrasa, Jaume
Tetrahedron, 1989 , vol. 45, # 3 p. 863 - 868
反应条件
1: 1.) p-toluene-sulfonic acid, 2.) NaI / 1.) THF, RT, 1 h, 2.) RT, 24 h, acetone 2: 44 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 degC, 30 min and RT, 4 h 3: 76 percent / O2, p-toluenesulfonic acid / Sensitox / CH2Cl2 / 0.5 h / Irradiation; investigation of the photooxygenation of the hydroxy oxazoles View Scheme
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron, 1981 , vol. 37, # 23 p. 4059 - 4067
反应条件
1: 96 percent / borane, HCl / tetrahydrofuran; methanol / 2 h 2: 1.) p-toluene-sulfonic acid, 2.) NaI / 1.) THF, RT, 1 h, 2.) RT, 24 h, acetone 3: 44 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 degC, 30 min and RT, 4 h 4: 76 percent / O2, p-toluenesulfonic acid / Sensitox / CH2Cl2 / 0.5 h / Irradiation; investigation of the photooxygenation of the hydroxy oxazoles View Scheme
参考文献
Wasserman, Harry H.; Gambale, Ronald J.; Pulwer, Mitchell J.
Tetrahedron, 1981 , vol. 37, # 23 p. 4059 - 4067
反应条件
1: 97 percent / HCl / 3 h / 25 °C 2: 85 percent / diisopropylethylamine / 18 h / 150 °C / other reaction conditions 3: 1.) LiAlH4, 2.) H2O / 1.)Et2O, 2 h 4: methyltriphenoxyphosphonium iodide 5: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C 6: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 7: BF3 etherate / diethyl ether 8: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
1: 85 percent / diisopropylethylamine / 18 h / 150 °C / other reaction conditions 2: 1.) LiAlH4, 2.) H2O / 1.)Et2O, 2 h 3: methyltriphenoxyphosphonium iodide 4: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C 5: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 6: BF3 etherate / diethyl ether 7: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
1: methyltriphenoxyphosphonium iodide 2: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C 3: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 4: BF3 etherate / diethyl ether 5: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
1: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C 2: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 3: BF3 etherate / diethyl ether 4: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
1: 1.) LiAlH4, 2.) H2O / 1.)Et2O, 2 h 2: methyltriphenoxyphosphonium iodide 3: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C 4: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O 5: BF3 etherate / diethyl ether 6: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
反应条件
1: BF3 etherate / diethyl ether 2: 30 percent / aq. 3N HCl View Scheme
参考文献
Genet, Jean Pierre; Kahn, Philippe
Tetrahedron Letters, 1980 , vol. 21, p. 1521 - 1524
