5-氯-2-硝基-4-(三氟甲基)苯胺合成路线 （共 10 条）
反应条件
ammonia in 2-methoxy-ethanol T=100°C; 16 h;
参考文献
Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Calabri, Francesca Romana; Filacchioni, Guido; Galli, Alessandro; Costagli, Chiara; Carla, Vincenzo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 262 - 272
反应条件
hydrogenchloride Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
1: 12 h / 25 °C 2: concd. H2SO4, concd. HNO3 / 0 - 20 °C 3: concd. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
1: concd. H2SO4, concd. HNO3 / 0 - 20 °C 2: concd. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 22 p. 4367 - 4379
反应条件
1: diethyl malonate With potassium tert-butylate in dimethyl sulfoxide T=20 - 30°C; 2: 5-chloro-2-nitro-4-trifluoromethyl-phenylamine in dimethyl sulfoxide T=60°C; 20 h; 3: With hydrogenchloride; potassium hydroxide; water more than 3 stages;
参考文献
McArthur, Silvia Gatti; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes
Patent: US2007/72879 A1, 2007 ;
Location in patent: Page/Page column 10-11 ;
US 20070072879 A1
反应条件
1: diethyl malonate With potassium tert-butylate in dimethyl sulfoxide T=0 - 30°C; 2: 5-chloro-2-nitro-4-trifluoromethyl-phenylamine in dimethyl sulfoxide T=60°C; 20 h; 3: With potassium hydroxide in water; dimethyl sulfoxide T=23 - 100°C; 4 h;
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2005/123738 A1, 2005 ;
Location in patent: Page/Page column 25 ;
反应条件
tin(ll) chloride in ethanol; ethyl acetate T=70°C; 0.583333 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/56150 A1, 2008 ;
Location in patent: Page/Page column 182 ;
WO 2008/056150 A1
反应条件
potassium
T=55 - 60°C; 96 h;
参考文献
Binggeli, Alfred; Christ, Andreas Dominik; Green, Luke Gideon Granville; Guba, Wolfgang; Maerki, Hans-Peter; Martin, Rainer Eugen; Mohr, Peter
Patent: US2006/205718 A1, 2006 ;
Location in patent: Page/Page column 29 ;
US 20060205718 A1
反应条件
1: ethanol With potassium
T=0°C;
2: 5-chloro-2-nitro-4-trifluoromethyl-phenylamine T=55 - 60°C; 96 h;
3: With hydrogenchloride; water
pH=2;
参考文献
McArthur, Silvia Gatti; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes
Patent: US2007/72879 A1, 2007 ;
Location in patent: Page/Page column 12 ;
US 20070072879 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Beaulieu, Pierre L.; Coulombe, Rene; Fazal, Gulrez; Goulet, Sylvie; Poirier, Martin; Rancourt, Jean; Stammers, Timothy; Thavonekham, Bounkham
Patent: US2008/45516 A1, 2008 ;
Location in patent: Page/Page column 36 ;
