1-(2-甲氧苯基)哌嗪合成路线 （共 66 条）
反应条件
sodium t-butanolate in diethylene glycol dimethyl ether T=170°C; 0.5 h; Microwave irradiation;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
Location in patent: Page/Page column 105 ;
WO 2012/003418 A2
反应条件
tetrabutylammomium bromide; sodium carbonate in water T=20°C; Reflux;
参考文献
Narsaiah, A. Venkat; Nagaiah
Synthesis, 2010 , # 16 art. no. Z07610SS, p. 2705 - 2707
反应条件
copper(l) iodide; potassium carbonate in butanone T=100°C; 12 h;
参考文献
Subhas Bose; Narsimha Reddy; Chavhan, Sanjay W.
Synthesis, 2005 , # 14 art. no. Z03505SS, p. 2345 - 2348
反应条件
sodium hydroxide in water 0.166667 h;
参考文献
WO2005/94896 A2, ;
Page/Page column 21 ;
WO 2005/094896 A2
反应条件
1: With hydrogenchloride in methanol 2 h; 2: With sodium hydrogencarbonate in water Product distribution / selectivity;
参考文献
AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.
Patent: WO2011/72174 A1, 2011 ;
Location in patent: Page/Page column 107 ;
WO 2011/072174 A1
反应条件
dimethylsulfide borane complex in tetrahydrofuran Heating;
参考文献
Kruse, C. G.; Troost, J. J.; Cohen-Fernandes, P.; Linden, H. van der; Loon, J. D. van
Recueil des Travaux Chimiques des Pays-Bas, 1988 , vol. 107, # 4 p. 303 - 310
反应条件
sodium t-butanolate; [Pd2(dba)2]; tri-tert-butyl phosphine in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 39, # 7 p. 617 - 620
反应条件
tris-(dibenzylideneacetone)dipalladium(0)
反应条件
1: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 15 min; 2.) THF, 16 h, reflux 2: 98 percent / H2 / 10 percent Pd/C / methanol / 0.75 h / 25 °C 3: 86 percent / BH3*Me2S / tetrahydrofuran / Heating View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 107, # 4 p. 303 - 310
反应条件
diborane in tetrahydrofuran 1) 0 degC, 2 h; 2) 4 h, reflux;
参考文献
Cossec, B.; Marsura, A.; Luu-Duc, C.
Pharmazie, 1989 , vol. 44, # 9 p. 643
