1-(2-甲氧苯基)哌嗪合成路线 （共 66 条）
反应条件
1: 98 percent / H2 / 10 percent Pd/C / methanol / 0.75 h / 25 °C 2: 86 percent / BH3*Me2S / tetrahydrofuran / Heating View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 107, # 4 p. 303 - 310
反应条件
1: 83 percent / N,N'-carbonyldiimidazole / tetrahydrofuran / 16 h / 65 °C 2: 98 percent / H2 / 10 percent Pd/C / methanol / 0.75 h / 25 °C 3: 86 percent / BH3*Me2S / tetrahydrofuran / Heating View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 107, # 4 p. 303 - 310
反应条件
1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 100 °C / Inert atmosphere 2: hydrogenchloride / methanol / 2 h View Scheme
参考文献
WO2011/72174 A1, ;
WO 2011/072174 A1
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) 0 deg C, 30 min; room temp., 1 h, 2.) reflux, overnight; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 58, # 19 p. 5101 - 5106
反应条件
T=150°C; Inert atmosphere;
参考文献
Modi, Gyan; Antonio, Tamara; Reith, Maarten; Dutta, Aloke
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1557 - 1572
反应条件
1: 82 percent / diborane / tetrahydrofuran / 1) ice bath, 1 h; 2) 12 h, reflux 2: 90 percent / DCC / CH2Cl2 / 1.5 h / -30 °C 3: NaI, NaHCO3 / acetone / 48 h / Heating 4: 53.6 percent / diborane / tetrahydrofuran / 1) 0 degC, 2 h; 2) 4 h, reflux View Scheme
参考文献
Pharmazie, , vol. 44, # 9 p. 643
反应条件
1: 90 percent / DCC / CH2Cl2 / 1.5 h / -30 °C 2: NaI, NaHCO3 / acetone / 48 h / Heating 3: 53.6 percent / diborane / tetrahydrofuran / 1) 0 degC, 2 h; 2) 4 h, reflux View Scheme
参考文献
Pharmazie, , vol. 44, # 9 p. 643
反应条件
1: NaI, NaHCO3 / acetone / 48 h / Heating 2: 53.6 percent / diborane / tetrahydrofuran / 1) 0 degC, 2 h; 2) 4 h, reflux View Scheme
参考文献
Pharmazie, , vol. 44, # 9 p. 643
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1333
Collection of Czechoslovak Chemical Communications, , vol. 6, p. 211,218
反应条件
1.) DMSO, 25 deg C, 3 h, in dark, 2.) DMSO, 80 deg C, 3.5 h, hν; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 37, # 47 p. 8487 - 8488
