1-(2-甲氧苯基)哌嗪合成路线 （共 66 条）
反应条件
hydrogen bromide 90 h; Heating;
参考文献
Martin; Elgin Jr.; Mathiasen; Davis; Kesslick; Baldy; Shank; DiStefano; Fedde; Scott
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1052 - 1056
反应条件
zinc(II) perchlorate hexahydrate in dichloromethane T=20°C; 16 h;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
in isopropyl alcohol 30 h; Heating;
参考文献
Kothakonda, Kiran Kumar; Bose, D. Subhas
Chemistry Letters, 2004 , vol. 33, # 9 p. 1212 - 1213
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Subhas Bose; Narsimha Reddy; Chavhan, Sanjay W.
Synthesis, 2005 , # 14 art. no. Z03505SS, p. 2345 - 2348
反应条件
1: (S)-(+)-epichlorohydrin; α-naphthol With potassium carbonate in acetonitrile Heating; 2: N-(2-methoxyphenyl)-piperazine T=80°C; 0.166667 h; Further stages. Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
1: (R)-(-)-epichlorohydrin; α-naphthol With potassium carbonate in acetonitrile Heating; 2: N-(2-methoxyphenyl)-piperazine T=80°C; 0.166667 h; Further stages. Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
in isopropyl alcohol 30 h; Heating;
参考文献
Kothakonda, Kiran Kumar; Bose, D. Subhas
Chemistry Letters, 2004 , vol. 33, # 9 p. 1212 - 1213
反应条件
1: (S)-(+)-epichlorohydrin; α-naphthol With potassium carbonate in acetonitrile Heating; 2: N-(2-methoxyphenyl)-piperazine T=80°C; 0.166667 h; Further stages. Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
1: (R)-(-)-epichlorohydrin; α-naphthol With potassium carbonate in acetonitrile Heating; 2: N-(2-methoxyphenyl)-piperazine T=80°C; 0.166667 h; Further stages. Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
hydrogen bromide Heating;
参考文献
Kulig, Katarzyna; Sapa, Jacek; Maciag, Dorota; Filipek, Barbara; Malawska, Barbara
Archiv der Pharmazie, 2007 , vol. 340, # 9 p. 466 - 475
反应条件
1: 91 percent / potassium carbonate, / dimethylformamide / 18 h 2: 89 percent / BH3-Me2S / tetrahydrofuran / 2.5 h / Heating 3: 60 percent / triethylamine / CH2Cl2 / 20 °C View Scheme
参考文献
Pike, Victor W.; McCarron, Julie A.; Hume, Susan P.; Ashworth, Sharon; Opacka-Juffry, Jolanta; et al.
Medicinal Chemistry Research, 1995 , vol. 5, # 2/3 p. 208 - 227
