1-(2-甲氧苯基)哌嗪合成路线 （共 66 条）
反应条件
in water
T=20°C; 0.666667 h;
参考文献
Kamal, Ahmed; Reddy, J. Surendranadha; Bharathi, E. Vijaya; Dastagiri
Tetrahedron Letters, 2008 , vol. 49, # 2 p. 348 - 353
反应条件
acetic acid in ethanol
5 h; Heating;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
acetic acid in ethanol
5 h; Heating;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C;
参考文献
Guo, Dong; Xia, Lizi; Van Veldhoven, Jacobus P. D.; Hazeu, Marc; Mocking, Tamara; Brussee, Johannes; Ijzerman, Adriaan P.; Heitman, Laura H.
ChemMedChem, 2014 , vol. 9, # 4 p. 752 - 761
参考文献
Bristol-Myers Company
Patent: US4585773 A1, 1986 ;
US 4585773 A
反应条件
benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid in N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US5464788 A1, 1995 ;
反应条件
sodium hydroxide in acetone
T=20°C; 48 h;
参考文献
Mahesh; Venkatesha Perumal; Pandi
Pharmazie, 2005 , vol. 60, # 6 p. 411 - 414
反应条件
triethylamine in acetonitrile
T=20°C; 40 h;
参考文献
Karramkam, Mylene; Hinnen, Francoise; Berrehouma, Myriam; Hlavacek, Christophe; Vaufrey, Francoise; Halldin, Christer; McCarron, Julie A.; Pike, Victor W.; Dolle, Frederic
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2769 - 2782
参考文献
Hoffmann-La Roche Inc.
Patent: US4202978 A1, 1980 ;
US 4202978 A
反应条件
in toluene
Alkylation; 6 h; Heating;
参考文献
Caliendo, Giuseppe; Fiorino, Ferdinando; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Severino, Beatrice; Bruni, Giancarlo; Romeo, Maria Rosaria
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 533 - 538
