3-碘-4-甲氧基苯甲酸甲酯合成路线 （共 16 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in benzene Dehalogenation; Suzuki cross-coupling; transesterification; Heating;
参考文献
Tetrahedron, , vol. 56, # 49 p. 9655 - 9662
反应条件
1: copper-powder / 260 °C 2: aqueous hydriodic acid 3: concentrated aqueous HCl / 270 °C View Scheme
参考文献
Yakugaku Zasshi, , vol. 50, p. 183,201; dtsch. Ref. S. 24
Chem.Abstr., , p. 3505
反应条件
lithium hydroxide in tetrahydrofuran; methanol; water T=20°C; 8 h;
参考文献
UNIVERSITY OF KANSAS
Patent: US2011/82098 A1, 2011 ;
反应条件
1: With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=80°C; 18 h; 2: 3-iodo-4-methoxybenzoic acid methyl ester; 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in 1,4-dioxane T=80°C; 18 h;
参考文献
US6680401 B1, ;
Page column 60 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=20 - 90°C; 16 h;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 18 p. 6234 - 6253
反应条件
1: cyclohexylMgCl With zinc(II) chloride in tetrahydrofuran
T=20°C; 0.333333 h;
2: 3-iodo-4-methoxybenzoic acid methyl ester With Pd0(tris(tert-butyl)phosphine)2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; 0.666667 h;
参考文献
Genelabs Technologies, Inc.
Patent: US2007/32488 A1, 2007 ;
Location in patent: Page/Page column 30 ;
