2,2,2-三氟乙酰胺合成路线 （共 158 条）
反应条件
potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride in acetonitrile
0.5 h; Heating;
参考文献
Landini, Dario; Penso, Michele
Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 420 - 423
反应条件
byproducts: NF3,HF; At -6°C.;
参考文献
Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84
反应条件
potassium phosphate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in N,N-dimethyl-formamide
T=45°C;
参考文献
Tao, Chuan-Zhou; Li, Juan; Fu, Yao; Liu, Lei; Guo, Qing-Xiang
Tetrahedron Letters, 2008 , vol. 49, # 1 p. 70 - 75
反应条件
potassium carbonate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in 1,4-dioxane
T=75°C;
参考文献
Tao, Chuan-Zhou; Li, Juan; Fu, Yao; Liu, Lei; Guo, Qing-Xiang
Tetrahedron Letters, 2008 , vol. 49, # 1 p. 70 - 75
反应条件
oxalyl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine
1.) CH2Cl2, -78 deg C, 30 min; 2.) CH2Cl2, -78 deg C, 15 min, then --> room temp., 10 h; Yield given. Multistep reaction;
参考文献
Nakajima, Noriyuki; Saito, Miho; Ubukata, Makoto
Tetrahedron Letters, 1998 , vol. 39, # 31 p. 5565 - 5568
反应条件
in benzene
reflux, 96h;
参考文献
Rynbrandt, R. H.; Nishizawa, E.- E.; Balogoyen, D. P.; Mendoza, A. R.; Annis, U. A.
J. Med. Chem., 1981 , vol. 24, p. 1507 - 1510
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Gmelin Handbook: F: PerFHalOrg.SVol.1, 6.2.1.2, page 193 - 198
Show Details
The Upjohn Co., Rynbrandt, R. H.
Patent: DE2836742 , 1979 ;
C.A., 1979 , vol. 91, p. 20490
反应条件
(i) P2O5, (ii) /BRN= 605971/, Na, Et2O; Multistep reaction;
参考文献
Gorbatenko,V.I. et al.
Journal of Organic Chemistry USSR (English Translation), 1979 , vol. 15, p. 1849 - 1852
Zhurnal Organicheskoi Khimii, 1979 , vol. 15, p. 2047 - 2051
反应条件
potassium carbonate; tetrabutylammomium bromide in acetonitrile
T=80°C; 2 h;
参考文献
Landini, Dario; Penso, Michele
Synthetic Communications, 1988 , vol. 18, # 8 p. 791 - 800
反应条件
potassium carbonate; tetrabutylammomium bromide in N,N-dimethyl-formamide
T=80°C; 2 h;
参考文献
Landini, Dario; Penso, Michele
Synthetic Communications, 1988 , vol. 18, # 8 p. 791 - 800
反应条件
sodium hydride
1.) DMF, 20 deg C, 1 h, 2.) 80 deg C, 18 h; Yield given. Multistep reaction;
参考文献
Harland, Philip A.; Hodge, Philip; Maughan, Wilfrid; Wildsmith, Eric
Synthesis, 1984 , # 11 p. 941 - 943
