4-[3-(乙酰基-羟基氨基)丙基氨基]-2-[2-[3-(乙酰基-羟基氨基)丙基氨基]-2-氧代乙基]-2-羟基-4-氧代丁酸合成路线 （共 19 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; water P=760 Torr; 3 h; Ambient temperature; Yield given;
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
trifluoroacetic acid 0.5 h;
参考文献
Milewska, Maria J.; Chimiak, Andrzej; Glowacki, Zdzislaw
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 3 p. 447 - 456
反应条件
1: 55 percent / triethylamine / acetonitrile / 1 h / 25 °C 2: 80 percent / CH2Cl2 / 1 h / Heating 3: 80 percent / aq. NaOH / methanol / 0.08 h / 0 °C 4: aq. TFA / 1 h / 20 °C View Scheme
参考文献
Milewska, Maria J.; Chimiak, Andrzej; Glowacki, Zdzislaw
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 3 p. 447 - 456
反应条件
1: 80 percent / CH2Cl2 / 1 h / Heating 2: 80 percent / aq. NaOH / methanol / 0.08 h / 0 °C 3: aq. TFA / 1 h / 20 °C View Scheme
参考文献
Fadeev, Evgeny A.; Luo, Minkui; Groves, John T.
Journal of the American Chemical Society, 2004 , vol. 126, # 38 p. 12065 - 12075
反应条件
1: 80 percent / aq. NaOH / methanol / 0.08 h / 0 °C 2: aq. TFA / 1 h / 20 °C View Scheme
参考文献
Fadeev, Evgeny A.; Luo, Minkui; Groves, John T.
Journal of the American Chemical Society, 2004 , vol. 126, # 38 p. 12065 - 12075
反应条件
1: 75 percent / Et3N / 21 h / Heating 2: 42 percent / DCC / acetonitrile / 1.) 0 deg C, 0.5 h, 2.) room temperature, 5 h 3: 1.) Et3N / 1.) MeCN, room temperature, 1 h, 2.) 2-3 h room temperature 4: tetrahydrofuran; H2O / 2 h 5: H2 / 5percent Pd/C / tetrahydrofuran; H2O / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
1: 97 percent / HCl gas / diethyl ether / 0 °C 2: Et3N / acetonitrile / 3.5 h / Ambient temperature 3: H2 / Pd/C / tetrahydrofuran; H2O View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
1: 42 percent / DCC / acetonitrile / 1.) 0 deg C, 0.5 h, 2.) room temperature, 5 h 2: 1.) Et3N / 1.) MeCN, room temperature, 1 h, 2.) 2-3 h room temperature 3: tetrahydrofuran; H2O / 2 h 4: H2 / 5percent Pd/C / tetrahydrofuran; H2O / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
1: 41 percent / DCC / acetonitrile / 1.) 0 deg C, 0.5 h, 2.) room temperature, 5 h 2: Et3N / acetonitrile / 3.5 h / Ambient temperature 3: H2 / Pd/C / tetrahydrofuran; H2O View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
1: Et3N / acetonitrile / 3.5 h / Ambient temperature 2: H2 / Pd/C / tetrahydrofuran; H2O View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
