4-[3-(乙酰基-羟基氨基)丙基氨基]-2-[2-[3-(乙酰基-羟基氨基)丙基氨基]-2-氧代乙基]-2-羟基-4-氧代丁酸合成路线 （共 19 条）
反应条件
1: 1.) Et3N / 1.) MeCN, room temperature, 1 h, 2.) 2-3 h room temperature 2: tetrahydrofuran; H2O / 2 h 3: H2 / 5percent Pd/C / tetrahydrofuran; H2O / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
1: Et3N / acetonitrile / 3.5 h / Ambient temperature 2: H2 / Pd/C / tetrahydrofuran; H2O View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
1: tetrahydrofuran; H2O / 2 h 2: H2 / 5percent Pd/C / tetrahydrofuran; H2O / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; water
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
反应条件
1: 63 percent / HClO4 / 72 h 2: 82 percent / 2 M NaOH / methanol; H2O / 3 h 3: 85 percent / DCCI / dioxane; ethyl acetate / 15 h 4: 98 percent / Et3N / dioxane / 2.5 h 5: 80 percent / 0.75 M NaHCO3 / ethyl acetate; H2O / 3 h 6: 90 percent / H2 / 10 percent Pd/C / ethanol 7: 92 percent / CF3COOH / 0.5 h View Scheme
参考文献
Milewska, Maria J.; Chimiak, Andrzej; Glowacki, Zdzislaw
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 3 p. 447 - 456
反应条件
1: 85 percent / DCCI / dioxane; ethyl acetate / 15 h 2: 98 percent / Et3N / dioxane / 2.5 h 3: 80 percent / 0.75 M NaHCO3 / ethyl acetate; H2O / 3 h 4: 90 percent / H2 / 10 percent Pd/C / ethanol 5: 92 percent / CF3COOH / 0.5 h View Scheme
参考文献
Milewska, Maria J.; Chimiak, Andrzej; Glowacki, Zdzislaw
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 3 p. 447 - 456
反应条件
1: 82 percent / 2 M NaOH / methanol; H2O / 3 h 2: 85 percent / DCCI / dioxane; ethyl acetate / 15 h 3: 98 percent / Et3N / dioxane / 2.5 h 4: 80 percent / 0.75 M NaHCO3 / ethyl acetate; H2O / 3 h 5: 90 percent / H2 / 10 percent Pd/C / ethanol 6: 92 percent / CF3COOH / 0.5 h View Scheme
参考文献
Milewska, Maria J.; Chimiak, Andrzej; Glowacki, Zdzislaw
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 3 p. 447 - 456
反应条件
1: 80 percent / 0.75 M NaHCO3 / ethyl acetate; H2O / 3 h 2: 90 percent / H2 / 10 percent Pd/C / ethanol 3: 92 percent / CF3COOH / 0.5 h View Scheme
参考文献
Milewska, Maria J.; Chimiak, Andrzej; Glowacki, Zdzislaw
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 3 p. 447 - 456
反应条件
1: 90 percent / H2 / 10 percent Pd/C / ethanol 2: 92 percent / CF3COOH / 0.5 h View Scheme
参考文献
Milewska, Maria J.; Chimiak, Andrzej; Glowacki, Zdzislaw
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 3 p. 447 - 456
