[1-甲基-2-(4’-丁酸乙酯基)-5-N, N-二(2’-羟基乙基)]-1H -苯并咪唑合成路线 （共 15 条）
反应条件
1: sulfuric acid / 10 h / |Reflux 2: iron sulphate heptahydrate; hydrogen; Iron (III) nitrate nonahydrate; 5 Pd/C / ethanol / 3000.3 Torr 3: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / |Large scale View Scheme
反应条件
1: water / 4.5 h / 70 °C 2: hydrogen; / ethanol / 2 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 3: ethanol / 5 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 4: hydrogenchloride / water / 2.5 h / 60 °C / pH Ca. 2 View Scheme
反应条件
1: hydrogen; / ethanol / 2 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 2: ethanol / 5 h / 23 °C / 2585.81 - 3102.97 Torr / |Inert atmosphere 3: hydrogenchloride / water / 2.5 h / 60 °C / pH Ca. 2 View Scheme
反应条件
1: With thionyl chloride in dichloromethane T=-1 - 22°C; 17 h; 2: With hydrogenchloride in water T=75°C;
参考文献
US2014/31560 A1, ;
Paragraph 0113; 0114; 0115; 0116; 0117; 0118 ;
反应条件
thionyl chloride in dichloromethane T=5 - 20°C; 16 h;
参考文献
US2014/31560 A1, ;
Paragraph 0123 ;
