4-(5-甲酰基-2-噻唑)哌嗪羧酸叔丁酯合成路线 (共 2 条)
反应条件
manganese(IV) oxide in dichloromethane 3 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2006/72436 A1, 2006 ;
Location in patent: Page/Page column 71 ;
反应条件
potassium carbonate in acetonitrile T=80°C; 8 h;
参考文献
Anandan, Sampath-Kumar; Ward, John S.; Brokx, Richard D.; Denny, Trisha; Bray, Mark R.; Patel, Dinesh V.; Xiao, Xiao-Yi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 5995 - 5999