2-(甲基氨基)苯甲酸乙酯合成路线 （共 18 条）
反应条件
in ethanol 15 h; Heating;
参考文献
Synlett, , # 8 p. 1269 - 1273
反应条件
lithium diisopropyl amide 1) THF, -78 to -20 deg C, 1h, 2) -40 deg C, 10 min; Yield given. Multistep reaction;
参考文献
Khanapure; Bhawal; Biehl
Tetrahedron Letters, 1990 , vol. 31, # 20 p. 2869 - 2972
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 50 °C 2: iron; acetic acid / 50 °C 3: sodium hydride / N,N-dimethyl acetamide / 0 °C 4: tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tert-butyl alcohol / 100 °C View Scheme
参考文献
Deng, Xianming; Yang, Qingkai; Kwiatkowski, Nicholas; Sim, Taebo; McDermott, Ultan; Settleman, Jeffrey E.; Lee, Jiing-Dwan; Gray, Nathanael S.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 3 p. 195 - 200
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 50 °C 2: iron; acetic acid / 50 °C 3: sodium hydride / N,N-dimethyl acetamide / 0 °C View Scheme
参考文献
Deng, Xianming; Yang, Qingkai; Kwiatkowski, Nicholas; Sim, Taebo; McDermott, Ultan; Settleman, Jeffrey E.; Lee, Jiing-Dwan; Gray, Nathanael S.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 3 p. 195 - 200
反应条件
lithium diisopropyl amide
1) THF, -78 to -20 deg C, 2) -40 deg C; Yield given. Multistep reaction;
参考文献
Khanapure; Bhawal; Biehl
Tetrahedron Letters, 1990 , vol. 31, # 20 p. 2869 - 2972
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 50 °C
2: iron; acetic acid / 50 °C
View Scheme
参考文献
Deng, Xianming; Yang, Qingkai; Kwiatkowski, Nicholas; Sim, Taebo; McDermott, Ultan; Settleman, Jeffrey E.; Lee, Jiing-Dwan; Gray, Nathanael S.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 3 p. 195 - 200
反应条件
1: Et3N / CH2Cl2 / 8 h / Ambient temperature
2: aq. KOH / 5 h
3: 96 percent / aq. HCl / 1 h
View Scheme
参考文献
Ukrainets, I. V.; Bezuglyi, P. A.; Treskach, V. I.; Turov, A. V.; Slobodzyan, S. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 5 p. 534 - 538
Khimiya Geterotsiklicheskikh Soedinenii, Sbornik, 1992 , # 5 p. 636 - 639
反应条件
1: Et3N / CH2Cl2 / 8 h / Ambient temperature
2: aq. KOH / 5 h
3: 96 percent / aq. HCl / 1 h
4: 89 percent / 2N aq. HCl / 5 h / Heating
View Scheme
参考文献
Ukrainets, I.V.; Gorokhova, O.V.; Taran, S.G.; Bezuglyi, P.A.; Turov, A.V.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 7 p. 829 - 836
Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 7 p. 958 - 966
