5-氯-2-噻吩羧酸甲酯合成路线 （共 12 条）
反应条件
sulfuric acid T=50 - 55°C; 12 - 20 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/98104 A1, 2008 ;
Location in patent: Page/Page column 109; 188 ;
WO 2008/098104 A1
反应条件
1 h; Heating; Yield given;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/2099 A2, 2006 ;
Location in patent: Page/Page column 77 ;
WO 2006/002099 A2
反应条件
molybdenum hexacarbonate T=150°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
反应条件
molybdenum hexacarbonate T=150°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
反应条件
N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride in acetic acid T=70°C; 24 h; with different molar ratio, with prereaction of the reagents; Product distribution;
参考文献
D'Auria; Mauriello
Synthesis, 1995 , # 3 p. 248 - 250
反应条件
molybdenum hexacarbonate T=150°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
反应条件
1: SOCl2 / 0.25 h / Heating 2: 1 h / Heating View Scheme
参考文献
Aitken, R. Alan; Bibby, Michael C.; Bielefeldt, Florian; Double, John A.; Laws, Andrea L.; Mathieu, Anne-Laure; Ritchie, Robert B.; Wilson, David W. J.
Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 405 - 411
反应条件
T=30 - 58°C; Rate constant;
参考文献
Imoto et al.
Nippon Kagaku Zasshi, 1956 , vol. 77, p. 804,807
Chem.Abstr., 1958 , p. 9066
反应条件
nitric acid T=0°C; 1 h;
参考文献
Japan Tobacco Inc.
Patent: EP1688420 A1, 2006 ;
Location in patent: Page/Page column 122 ;
反应条件
T=120°C; 48 h; Inert atmosphereHeating; Product distribution / selectivity;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; VENKAT REDDY, Buthukuri
Patent: WO2012/156983 A1, 2012 ;
Location in patent: Page/Page column 15-16 ;
