5-氯-2-噻吩羧酸甲酯合成路线 （共 12 条）
反应条件
ammonium hydroxide in n-heptane T=20°C; 36 h; Industry scale;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2011/152530 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
1: sulfuric acid; nitric acid 2: aqueous sulfuric acid View Scheme
参考文献
Hurd; Kreuz
Journal of the American Chemical Society, 1952 , vol. 74, p. 2965,2969
