2-(2,2,2-三氟乙氧基)苯甲酸合成路线 (共 2 条)
反应条件
1: 2,2,2-trifluoroethanol With sodium t-butanolate in DMF (N,N-dimethyl-formamide); ethyl acetate T=0 - 25°C; 1 h; 2: ortho-chlorobenzoic acid With copper(I) bromide in DMF (N,N-dimethyl-formamide) T=120°C; 5 h;
参考文献
Wang, Zhi-Xian; Li, Yuanqiang; Guntoori, Bhaskar Reddy
Patent: US2005/59825 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
potassium hydroxide in water
参考文献
Riker Laboratories, Inc.
Patent: US3996280 A1, 1976 ;