4-(4-羟基甲基-2-甲氧基-5-硝基苯氧基)丁酸合成路线 （共 5 条）
反应条件
1: With methanol; sodium hydroxide; water 16 h; 2: With hydrogenchloride in water pH=1;
参考文献
SPIROGEN LIMITED
Patent: WO2005/23814 A1, 2005 ;
Location in patent: Page/Page column 49; 52 ;
反应条件
sodium tetrahydroborate T=0 - 20°C; 12 h; Inert atmosphere;
参考文献
Griffin, Donald R.; Kasko, Andrea M.
Journal of the American Chemical Society, 2012 , vol. 134, # 31 p. 13103 - 13107
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere 2: nitric acid / 0 - 20 °C / Inert atmosphere 3: trifluoroacetic acid / water / 3 h / 90 °C / Inert atmosphere 4: sodium tetrahydroborate / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 31 p. 13103 - 13107
反应条件
1: nitric acid / 0 - 20 °C / Inert atmosphere 2: trifluoroacetic acid / water / 3 h / 90 °C / Inert atmosphere 3: sodium tetrahydroborate / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 31 p. 13103 - 13107
反应条件
1: trifluoroacetic acid / water / 3 h / 90 °C / Inert atmosphere 2: sodium tetrahydroborate / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 31 p. 13103 - 13107
