1-(三甲基硅烷基)-2-哌啶酮合成路线 （共 27 条）
参考文献
Salas, Marisa; Al-Khawaja, Ibtisam K.; Thomas, Michelle J.; Joule, John A.
Journal of Chemical Research, Miniprint, 1988 , # 7 p. 1666 - 1675
反应条件
1: LDA / tetrahydrofuran; hexane / 1.) -50 deg C, 45 min, 2.) -78 deg C, 7 h 2: 50percent H2O2 / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 1.5 h View Scheme
参考文献
Hua, Duy H.; Zhang, Fengqi; Chen, Jinshan; Robinson, Paul D.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 5084 - 5087
反应条件
in dichloromethane T=-80°C; Title compound not separated from byproducts;
参考文献
Albanov, A. I.; Baukov, Yu. I.; Voronkov, M. G.; Kramarova, E. P.; Larin, M. F.; Pestunovich, V. A.
J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 1 p. 246 - 248,216 - 217
反应条件
in acetonitrile T=80 - 85°C; 3 h;
参考文献
Uryupin, A. B.; Rakhov, I. A.; Kolesova, V. A.; Petrovskii, P. V.; Mastryukova, T. A.; Kabachnik, M. I.
Russian Chemical Bulletin, 1994 , vol. 43, # 9 p. 1556 - 1560
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1994 , # 9 p. 1644 - 1648
反应条件
bis(trimethylsilyl)-peroxide; acetic acid; lithium diisopropyl amide 1.) THF, hexane, -20 deg C, 1 h; 25 deg C, 12 h, 2.) CH2Cl2, 25 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Hua, Duy H.; Zhang, Fengqi; Chen, Jinshan; Robinson, Paul D.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 5084 - 5087
参考文献
Baukov, Yu. I.; Kramarova, E. P.; Shipov, A. G.; Oleneva, G. I.; Artamkina, O. B.; et al.
J. Gen. Chem. USSR (Engl. Transl.), 1989 , vol. 59, # 1.2 p. 127 - 145,110 - 125
反应条件
1: CH2Cl2 / -80 °C
2: CH2Cl2 / -80 deg C -> 20 deg C -> -80 deg C
View Scheme
参考文献
Baukov, Yu. I.; Kramarova, E. P.; Shipov, A. G.; Oleneva, G. I.; Artamkina, O. B.; et al.
J. Gen. Chem. USSR (Engl. Transl.), 1989 , vol. 59, # 1.2 p. 127 - 145,110 - 125
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
2.1: LDA / tetrahydrofuran; hexane / 3 h / -78 - 23 °C
3.1: aq. NH4Cl / tetrahydrofuran; hexane / 23 °C
4.1: 90 percent / benzylidene-bis(tricyclohexylphosphine)-dichlororuthenium / CH2Cl2 / 3 h / 23 °C
5.1: 97 percent / n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 - 23 °C
6.1: LiEt3BH / tetrahydrofuran / 0.75 h / -78 °C
6.2: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 12 h / 23 °C
View Scheme
参考文献
Trzoss, Michael; Brimble, Margaret A.
Synlett, 2003 , # 13 p. 2042 - 2046
反应条件
in acetonitrile
T=80 - 85°C; 3 h; Yields of byproduct given;
参考文献
Uryupin, A. B.; Rakhov, I. A.; Kolesova, V. A.; Petrovskii, P. V.; Mastryukova, T. A.; Kabachnik, M. I.
Russian Chemical Bulletin, 1994 , vol. 43, # 9 p. 1556 - 1560
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1994 , # 9 p. 1644 - 1648
反应条件
in tetrahydrofuran
3 h; Inert atmosphereReflux;
参考文献
Chang, Mingxin; Li, Wei; Hou, Guohua; Zhang, Xumu
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3121 - 3125
