3-氯-1,1-二乙氧基丙烷合成路线 （共 57 条）
反应条件
ethanol; sodium ethanolate
T=130 - 140°C; Erhitzen unter Druck;
参考文献
Ellinger
Chemische Berichte, 1905 , vol. 38, p. 2886
反应条件
potassium iodide in ethanol; water
参考文献
Merck and Co., Inc.
Patent: US4025625 A1, 1977 ;
反应条件
Yield given. Multistep reaction;
参考文献
Barluenga, Jose; Fernandez, Jose R.; Yus, Miguel
Journal of the Chemical Society, Chemical Communications, 1987 , # 20 p. 1534 - 1535
反应条件
1: (i) NaH, DMF, mineral oil, (ii) /BRN= 1698609/
2: aq. H2O2, ammonium molybdate / methanol / 90 h / 20 °C
3: (i) nBuLi, THF, hexane, (ii) /BRN= 1731290/, (iii) Na-Hg, MeOH
View Scheme
参考文献
Julia,M.; Badet,B.
Bulletin de la Societe Chimique de France, 1975 , p. 1363 - 1366
反应条件
1: With naphthalene; lithium in tetrahydrofuran
Ring cleavage;
2: With copper dichloride in tetrahydrofuran
T=-78°C; Dimerization; 0.75 h;
3: With ammonium chloride in tetrahydrofuran
T=-78 - 20°C; Hydrolysis;
参考文献
Pastor, Isidro M.; Yus, Miguel
Tetrahedron Letters, 2000 , vol. 41, # 10 p. 1589 - 1592
反应条件
1: (i) NaH, DMF, mineral oil, (ii) /BRN= 1698609/
2: aq. H2O2, ammonium molybdate / methanol / 90 h / 20 °C
3: (i) nBuLi, THF, hexane, (ii) /BRN= 471308/, (iii) Na-Hg, MeOH
View Scheme
参考文献
Julia,M.; Badet,B.
Bulletin de la Societe Chimique de France, 1975 , p. 1363 - 1366
参考文献
Brabant
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1913 , vol. 86, p. 212
