2-氨基-4-硝基苯甲酸甲酯合成路线 （共 19 条）
反应条件
1: alcohol; sulfuric acid 2: sulfuric acid View Scheme
参考文献
Wheeler; Barnes
American Chemical Journal, 1898 , vol. 20, p. 222
参考文献
Hay, Michael P.; Sykes, Bridget M.; Denny, William A.; O'Connor, Charmian J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2759 - 2770
反应条件
1: 37 percent / SO2Cl2; glac. AcOH / 30 °C 2: 100 percent / aq. NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Cordi, Alex A; Desos, Patrice; Ruano, Elisabeth; Al-Badri, Hashim; Fugier, Claude; Chapman, Astrid G; Meldrum, Brian S; Thomas, Jean-Yves; Roger, Anita; Lestage, Pierre
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 10 p. 787 - 802
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=65°C; 1.16667 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/138033 A1, 2007 ;
Location in patent: Page/Page column 32-33 ;
反应条件
ammonium hydroxide; sulfur dioxide; copper dichloride; sodium nitrite Multistep reaction;
参考文献
Nerenberg, Jennie B.; Erb, Jill M.; Thompson, Wayne J.; Lee, Hee-Yoon; Guare, James P.; Munson, Peter M.; Bergman, Jeffrey M.; Huff, Joel R.; Broten, Theodore P.; Chang, Raymond S. L.; Chen, Tsing B.; O'Malley, Stacey; Schorn, Terry W.; Scott, Ann L.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 18 p. 2467 - 2472
反应条件
1: 61 percent / copper(II) acetate / dimethylformamide / 12 h / 100 °C
2: polyphosphoric ethyl ester / CHCl3 / 1 h / Heating
3: aq. NaOH / ethanol / 0.17 h / Heating
View Scheme
参考文献
Rewcastle, Gordon W.; Denny, William A.
Synthesis, 1985 , # 2 p. 220 - 222
反应条件
1: 93 percent / dioxane / 1 h / Heating
2: 52 percent / Raney nickel / ethanol / Heating
View Scheme
参考文献
Nesterova, I. N.; Radkevich, T. P.; Granik, V. G.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 11 p. 786 - 789
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 11 p. 28 - 30
反应条件
1: 35 percent / dioxane / 1 h / Heating
2: 60 percent / Raney nickel / ethanol / Heating
View Scheme
参考文献
Nesterova, I. N.; Radkevich, T. P.; Granik, V. G.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 11 p. 786 - 789
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 11 p. 28 - 30
反应条件
(i) ClCH2CH2Cl, (ii) piperidine, dioxane; Multistep reaction;
参考文献
Kampe,K.-D.
Synthesis, 1976 , p. 469 - 471
