1-甲基-2-苯基吲哚合成路线 （共 124 条）
反应条件
sulfuric acid; silver(I) acetate; palladium dichloride in N,N-dimethyl-formamide; acetonitrile T=100°C; 0.666667 h; Sealed tubeMicrowave irradiation; regioselective reaction;
参考文献
Miao, Tao; Li, Pinhua; Wang, Guan-Wu; Wang, Lei
Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 3185 - 3190
反应条件
1: 2-(2-phenylethynyl)aniline With potassium hydride in 1-methyl-pyrrolidin-2-one T=20°C; 2 h; 2: methyl iodide in 1-methyl-pyrrolidin-2-one 0.5 h;
参考文献
Koradin, Christopher; Dohle, Wolfgang; Rodriguez, Alain L.; Schmid, Bertram; Knochel, Paul
Tetrahedron, 2003 , vol. 59, # 9 p. 1571 - 1587
反应条件
copper diacetate; acetic acid; palladium diacetate T=120°C; P=760.051 Torr; 3 h;
参考文献
Organic Letters, , vol. 9, # 16 p. 3137 - 3139
反应条件
1: 85 percent / NaBH4 / 5percent Pd/C / tetrahydrofuran; H2O / 18 h / 20 °C 2: 86 percent / tetrahydrofuran / 5 h / Heating 3: 73 percent / NaH / various solvent(s); dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 2 p. 387 - 401
反应条件
1: 1-methyl-1H-indole With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane; pentane T=20°C; 0.5 h; Inert atmosphere; 2: chlorobenzene in tetrahydrofuran; hexane; pentane T=20°C; 1.5 h; Inert atmosphere;
参考文献
Truong, Thanh; Daugulis, Olafs
Journal of the American Chemical Society, 2011 , vol. 133, # 12 p. 4243 - 4245
反应条件
zinc(II) chloride T=130°C;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 236, p. 158
DE38784 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 1, p. 153
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in hexane; toluene T=20°C; 3 h; 2: benzoic acid N,N'-dimethyl-N'-phenylhydrazide in hexane; toluene 48 h; Reflux;
参考文献
Hisler, Kevin; Commeureuc, Aurelien G.J.; Zhou, Sheng-ze; Murphy, John A.
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3290 - 3293
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=60°C; Substitution; 3 h;
参考文献
Ishikura, Minoru; Agata, Isao; Katagiri, Nobuya
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 4 p. 873 - 879
反应条件
1: 87 percent / BF3*OEt2 / toluene / 16 h / 20 °C 2: 85 percent / NaBH4 / 5 percent Pd/C / tetrahydrofuran; H2O / 18 h / 20 °C 3: 86 percent / tetrahydrofuran / 5 h / Heating 4: 73 percent / NaH / various solvent(s); dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 2 p. 387 - 401
反应条件
silver hexafluoroantimonate in 1,2-dichloro-ethane T=80°C; Inert atmosphereGloveboxSchlenk technique;
参考文献
Liu, Jun; Xie, Xin; Liu, Yuanhong
Chemical Communications, 2013 , vol. 49, # 100 p. 11794 - 11796
